Events and Medicine Grand Rounds Schedule 22 May May PhD Convocation Wed May 22 2024, 12:00 PM Speaker: Keynote Speaker Dr. Hannes BuelowProfessor Departments of Genetics & Neuroscience Robbins Auditorium renee.rodriguez@einsteinmed.edu More A Celebration of our PhD Graduates and their Mentors 23 May May Pediatrics Research Rounds "Reaching into the Heart – Intracardiac Thrombolysis” Thu May 23 2024, 12:15 PM Speaker: Dominder Kaur, MBBS, MScAssistant Professor of Pediatrics Division of Hematology, Oncology & Stem Cell Transplantation; Department of Pediatrics Columbia University Irving Medical Center (CUIMC), NY CHAM 2 Room 1 and via Zoom, Montefiore noodal@montefiore.org More All Faculty and Trainees are Encouraged to Attend (This seminar will be broadcasted via Zoom and to the following locations: Van Etten 6A01 Conf. Room; Wakefield: 4th Fl. Pediatrics Conf room; New Rochelle: NICU Work Room (4th Fl.) Zoom Access available via: https://einsteinmed.zoom.us/j/98562641605 About this conference: Pediatric Research Rounds is a weekly interactive seminar to engage faculty and fellows in discussion about ongoing clinical, translational, and basic science research in the Department of Pediatrics and at Albert Einstein College of Medicine. The goals are to 1) facilitate opportunities for multi-investigator collaboration through presentation of new/unpublished data and research ideas and 2) foster the culture of academic excellence at CHAM/Einstein. Speakers are tasked with exploring areas of potential research overlap with other investigators. The conference is video simulcast from CHAM to many off-site locations including Einstein, New Rochelle, and Wakefield. We welcome additional participants. Category 1 CME credit is awarded. 28 May May Biochemistry Seminar Series "Cellular Mechanisms for Control of G Quadruplex DNA" Tue May 28 2024, 12:00 PM Speaker: Tovah Day, Ph.D.Assistant Professor, Department of Biology Northeastern University 3rd Floor Lecture Hall, Forchheimer david.shechter@einsteinmed.edu More G quadruplexes are non-canonical DNA secondary structures formed from stacked tetrads of Hoogsteen-bonded guanines. A DNA sequence with four guanine repeats (e.g. G3+N1-7G3+N1-7G3+N1-7G3+) can either assume a G quadruplex (G4) structure or the duplex B form. In cells, the formation of G4 structures must be carefully controlled both because G4s have important roles in fundamental processes including transcription and replication and because G4s trigger genome instability in the form of DNA breaks and mutations. However, the factors that determine the propensity of a G4 motif to form a G4 structure in cells are incompletely understood. The cell-type specificity observed in the landscapes of G4 structures implies the potential for chromatin-dependent regulation of G4 formation. We have identified eight chromatin modifications that control G4 DNA formation. Recently, we have focused on the chromatin remodeling complexes that contain BAZ2 (bromodomain adjacent zinc finger) family members BAZ2A and BAZ2B. BAZ2 activity suppresses structured G4s throughout the genome and protects from G4-mediated DNA damage. Taken together, our data suggest a novel role for chromatin remodeling, particularly BAZ2, in modulating G4 structures and influencing genome stability. 29 May May Einstein-MSSM Wednesday Joint WIP Seminar Wed May 29 2024, 12:00 PM Speaker: Mark A. Rossi, PhDAssistant Professor, Department of Psychiatry Child Health Institute of New Jersey Brain Health Institute; Rutgers University - Robert Wood Johnson Medical School 351, Price Center/Block Pavilion katherine.paulus@einsteinmed.edu More Einstein-MSSM Wednesday Joint WIP Seminar “Lateral Hypothalamic Control of Feeding: Implications for Obesity” If you are unable to attend in person, zoom information below https://mountsinai.zoom.us/j/95709436671 Meeting ID: 957 0943 6671 Next