New Publication Highlights

A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10. doi: 10.1016/j.stem.2024.02.004.
Authors: Massimo Bonora, Claudia Morganti, Nick van Gastel, Kyoko Ito, Enrica Calura, Ilaria Zanolla, Letizia Ferroni, Yang Zhang, Yookyung Jung, Gabriele Sales, Paolo Martini, Takahisa Nakamura, Francesco Massimo Lasorsa, Toren Finkel, Charles P Lin, Barbara Zavan, Paolo Pinton, Irene Georgakoudi, Chiara Romualdi, David T Scadden, Keisuke Ito The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore
Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2303713120. doi: 10.1073/pnas.2303713120. Epub 2023 Dec 13. PMID: 38091291. PMCID: PMC10743364.
Authors: Ryan Pekson, Felix G. Liang, Joshua L. Axelrod, Jaehoon Lee, Dongze Qin, Andre J. H. Wittig, Victor M. Paulino, Min Zheng, Pablo M. Peixoto, Richard N. Kitsis A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response–Dependent Survival of Quiescent Cancer Cells.
Clinical Cancer Research. 2023, DECEMBER 15
Authors: Veronica Calvo, Wei Zheng, Anna Adam-Artigues, Kirk A. Staschke, Xin Huang, Julie F. Cheung, Ana Rita Nobre, Sho Fujisawa, David Liu, Maria Fumagalli, David Surguladze, Michael E. Stokes, Ari Nowacek, Mark Mulvihill, Eduardo F. Farias, Julio A. Aguirre-Ghiso. Clinical Cancer Research. 2023 A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
Dev Cell. 2023, November 15
Authors: Yu Liu, Peter John, Kenta Nishitani, Jihong Cui, Christopher D Nishimura, John R Christin, Nicole Couturier, Xiaoxin Ren, Yao Wei, Marc C Pulanco, Phillip M Galbo Jr, Xusheng Zhang, Wenyan Fu, Wei Cui, Boris A Bartholdy, Deyou Zheng, Gregoire Lauvau, Susan A Fineberg, Maja H Oktay, Xingxing Zang, Wenjun Guo. Dev Cell. 2023 Intestinal stem cell aging at single-cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics.
Aging Cell. 2023 Mar 2.
Authors: Jiahn Choi, Michele Houston, Ruixuan Wang, Kenny Ye, Wenge Li, Xusheng Zhang, Derek M. Huffman, Leonard H. Augenlicht. Aging Cell. 2023;22:e13802. Chikungunya virus cell-to-cell transmission is mediated by intercellular extensions in vitro and in vivo
Nat Microbiol. 2023 Aug 17.
Authors: Peiqi Yin, Bennett J Davenport, Judy J Wan, Arthur S Kim, Michael S Diamond, Brian C Ware, Karen Tong, Thérèse Couderc, Marc Lecuit, Jonathan R Lai, Thomas E Morrison, Margaret Kielian DNA selection by the master transcription factor PU.1
Cell Rep. 2023 Jun 22;42(7):112671.
Authors: J Ross Terrell, Samuel J Taylor, Amelia L Schneider, Yue Lu, Tyler N Vernon, Suela Xhani, Ryan H Gumpper, Ming Luo, W David Wilson, Ulrich Steidl, Gregory M K Poon Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance
Elife. 2023 Jun 5;12:e69322.
Authors: Virginia Folgado-Marco, Kristina Ames, Jacky Chuen, Kira Gritsman, Nicholas E Baker 5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling
Cell Rep. 2023 May 29:112560.
Authors: Deepak K Singh, Saul Carcamo, Eduardo F Farias, Dan Hasson, Wei Zheng, Dan Sun, Xin Huang, Julie Cheung, Ana Rita Nobre, Nupura Kale, Maria Soledad Sosa, Emily Bernstein, Julio A Aguirre-Ghiso Comparative analysis of Tet2 catalytic-deficient and knockout bone marrow over time
Exp Hematol. 2023 May 22:S0301-472X(23)00227-8.
Authors: Julio C Flores, Kyoko Ito, Cheng-Yen Huang, Qin Tang, Chie Yanase, Keisuke Ito, Meelad M Dawlaty Maintenance of a short-lived protein required for long-term memory involves cycles of transcription and local translation
Neuron. 2023 Apr 19:S0896-6273(23)00267-2.
Authors: Sulagna Das, Pablo J Lituma, Pablo E Castillo, Robert H Singer Intestinal stem cell aging at single-cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics
Aging Cell. 2023 May;22(5):e13802.
Authors: Jiahn Choi, Michele Houston, Ruixuan Wang, Kenny Ye, Wenge Li, Xusheng Zhang, Derek M Huffman, Leonard H Augenlicht PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells
Sci Adv. 2023 Feb 22;9(8):eade8222.
Authors: Kristina Ames, Imit Kaur, Yang Shi, Meng M Tong, Taneisha Sinclair, Shayda Hemmati, Shira G Glushakow-Smith, Ellen Tein, Lindsay Gurska, Ulrich Steidl, Robert Dubin, Jidong Shan, Cristina Montagna, Kith Pradhan, Amit Verma, Kira Gritsman Human SMARCA5 is continuously required to maintain nucleosome spacing
Mol Cell. 2023 Feb 16;83(4):507-522.e6.
Authors: Monica L Bomber, Jing Wang, Qi Liu, Kelly R Barnett, Hillary M Layden, Emily Hodges, Kristy R Stengel, Scott W Hiebert MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state
Nat Cell Biol. 2023 Jan;25(1):145-158.
Authors: Jihong Cui, Chi Zhang, Ji-Eun Lee, Boris A Bartholdy, Dapeng Yang, Yu Liu, Piril Erler, Phillip M Galbo, Dayle Q Hodge, Danwei Huangfu, Deyou Zheng, Kai Ge, Wenjun Guo Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms
Clin Cancer Res. 2023 Mar 1;29(5):943-956.
Authors: Lindsay M Gurska, Rachel Okabe, Alexandra Schurer, Meng Maxine Tong, Mark Soto, Daniel Choi, Kristina Ames, Shira Glushakow-Smith, Allison Montoya, Ellen Tein, Linde A Miles, Haiying Cheng, Pamela Hankey-Giblin, Ross L Levine, Swati Goel, Balazs Halmos, Kira Gritsman MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells
Sci Adv. 2022 Dec 2;8(48):eabo0876.
Authors: Dan Sun, Deepak K Singh, Saul Carcamo, Dan Filipescu, Bassem Khalil, Xin Huang, Brett A Miles, William Westra, Karl Christoph Sproll, Dan Hasson, Emily Bernstein, Julio A Aguirre-Ghiso Drosophila SUMM4 complex couples insulator function and DNA replication control
Elife. 2022 Dec 2;11:e81828.
Authors: Evgeniya N Andreyeva, Alexander V Emelyanov, Markus Nevil, Lu Sun, Elena Vershilova, Christina A Hill, Michael-C Keogh, Robert J Duronio, Arthur I Skoultchi, Dmitry V Fyodorov PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets
Mol Cell. 2022 Dec 1;82(23):4428-4442.e7.
Authors: Susu Zhang, Jing Wang, Qi Liu, W Hayes McDonald, Monica L Bomber, Hillary M Layden, Jacob Ellis, Scott C Borinstein, Scott W Hiebert, Kristy R Stengel An improved imaging system that corrects MS2-induced RNA destabilization
Nat Methods. 2022 Dec;19(12):1558-1562.
Authors: Weihan Li, Anna Maekiniemi, Hanae Sato, Christof Osman, Robert H Singer Dietary iron restriction protects against vaso-occlusion and organ damage in murine sickle cell disease
Blood. 2023 Jan 12;141(2):194-199.
Authors: Huihui Li, Jacob S Kazmi, Sungkyun Lee, Dachuan Zhang, Xin Gao, Maria Maryanovich, Lidiane Torres, Divij Verma, Libusha Kelly, Yelena Z Ginzburg, Paul S Frenette, Deepa Manwani A glycan-based approach to cell characterization and isolation: Hematopoiesis as a paradigm
J Exp Med. 2022 Nov 7;219(11):e20212552.
Authors: Richard T Piszczatowski, Emily Schwenger, Sriram Sundaravel, Catarina M Stein, Yang Liu, Pamela Stanley, Amit Verma, Deyou Zheng, Ronald D Seidel, Steven C Almo, Robert A Townley, Hannes E Bülow, Ulrich Steidl Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine
J Exp Med. 2022 Nov 7;219(11):e20212228.
Authors: Ujunwa Cynthia Okoye-Okafor, Komal K Javarappa, Dimitrios Tsallos, Joseph Saad, Daozheng Yang, Chi Zhang, Lumie Benard, Victor J Thiruthuvanathan, Sally Cole, Stephen Ruiz, Madhuri Tatiparthy, Gaurav Choudhary, Stefanie DeFronzo, Boris A Bartholdy, Celine Pallaud, Pedro Marques Ramos, Aditi Shastri, Amit Verma, Caroline A Heckman, Britta Will ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung
Nat Cancer. 2022 Oct;3(10):1165-1180.
Authors: Ana Rita Nobre, Erica Dalla, Jihong Yang, Xin Huang, Lena Wullkopf, Emma Risson, Pedram Razghandi, Melisa Lopez Anton, Wei Zheng, Jose A Seoane, Christina Curtis, Ephraim Kenigsberg, Jianlong Wang, Julio A Aguirre-Ghiso