The mission of the Research Development Core is to ensure the future of Biology of Aging research through mentoring, pilot & feasibility
funding, and education.
Personnel
Director: Sofiya Milman, MD
Mentoring
Mentors include Einstein faculty who are members of the Einstein Nathan Shock center.
Pilot & Feasibility Awards
All members of the Einstein NSC, external members, and all other NSCs are eligible for P&F awards. The awards go toward the use of unique Einstein-NSC Core services.
P&F Applications
Call for Applications for Pilot & Feasibility Project Awards
Call for Applications for Core Use
P&F Awardees
Funded 2015
| Name |
Short Title |
| Arias-Perez, E |
Crosstalk between autophagic pathways with age |
| Delahaye, F |
Methylation signature of an advanced aging phenotype |
| Frenette, P |
Impact of aging on the bone marrow stem cells microenvironment |
Funded 2016
| Name |
Short Title |
| Buelow, H |
Comprehensive Approach Towards Understanding Neuronal Aging |
| Huffman, D |
Shlp2 in prevention of age-related functional and cognitive decline |
Funded 2017
| Name |
Short Title |
| Lee, D |
Central action of mitochondrial-derived peptides |
| Lamming, D |
Youthful circulating factors and cardiovascular disease |
| Promislow, D |
Epigenetics and epigenetic memory in aging fruit fly |
| Sell, C |
Longevity and Histone modifications |
| Shen, Y |
Defining regulators of aging in epithelial stem cells |
| Stout, M |
Age/sex specific metabolic responses to 17 a-estradiol |
Funded 2018
| Name |
Short Title |
| Radhakrishnan, S |
Nrf1 in the autophagy pathways |
| Zhu, Q |
C9ORF72 and autophagy in neurons |
| Stout, M |
Hypothalamic ERĪ± in age-related hepatic gluconeogenesis |
| Cohen, P |
MOTS-C can act centrally to regulate insulin sensitivity |
| Mar, J |
Metformin action with age in single cells using sc-RNA-SEQ |
| Mason, J |
Ovarian transplantation and DNA methylation fingerprints |
| Murach, K |
Skeletal muscle epigenetics with aging |
| Perls, T |
Somatic mutations in the blood of centenarians |
| Delahaye, F |
Single cell on microglia |
Funded 2019
| Name |
Short Title |
| Niedernhofer, L |
Autophagy profiling in cells from progeroid, DNA repair-deficient mice |
| Sutphin, G |
Evaluating mechanisms of improved proteostasis following interventions in kynurenine metabolism |
| Cortes, C |
Enhanced skeletal muscle proteostasis as a determinant of CNS aging |
| Skowronska-Krawczyk, D |
Role of ELOVL2 in aging |
| Allani, S |
Role of Methionine sulfoxide reductase (MSR) system in aging |
| Wang, G/Driscoll M |
The transcriptomic response to cytoplasmic or mitochondrial superoxide dysregulation |
Table 1. P&F applications from prior funding cycle (2015-2018) and those selected for funding in 2019.
Education
Seminar Series
Graduate Course in the Biology of Aging
Course Leaders: Ana Maria Cuervo, Md, PhD and Nir Barzilai, MD
The course presents an in-depth analysis of the biology of aging, building up from changes occurring at the molecular and cellular level and analyzing the consequences at the organism level. In addition, the influence of these age-related changes in what are commonly considered a disease of aging, such as neurodegeneration, diabetes, etc, will also be discussed. Topics will include: theories of aging, experimental models used to study of aging and longevity, impact of oxidative stress in cell and organ function, the metabolic syndrome of aging, functional changes in the immune, musculoskeletal and central nervous systems, genetic instability and genetics of aging and longevity. The goal of this course is to motivate an interest among our graduates for problems in biology of aging and to prepare them for the growing demand for future generations of aging researchers.
Hackathon: "Can we hack the Fountain of Youth?"
Hackathon leader: Jessica Mar, PhD
A friendly 2-day completion among Einstein graduate students, postdoctoral fellows, and faculty that aims to improve the science of aging via innovative investigations of existing aging-related datasets.
Links to the Einstein Hackathon 2017