Laboratory of Margarita Vigodner, Ph.D.



Dr. Margarita Vigodner's Lab:

Our previous research work focused on the studies of spermatogenesis and the development of new methodologies using flow cytometry and confocal microscopy for monitoring germ cell progression and to distinguish between normal and abnormal spermatogenesis.

Current research project in my group focuses on the characterization of the role of novel small proteins known as SUMO (small-ubiquitin-related modifiers) in testicular cells, sperm, stress response in the testis and the development of the testicular cancer.

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CDK14 expression is down-regulated by cigarette smoke in vivo and in vitro. 

By: Pollack D, XiaoY, Shrivasatava V, Levy A, Andrusier M, Jeanine D'Armiento J, Holz MK, and Vigodner M.Toxicol Lett. 2015 Apr 16;234(2):120-30. doi: 10.1016/j.toxlet.2015.02.006. Epub 2015 Feb 10.

Can your protein be sumoylated? A quick summary and important tips to study SUMO-modified proteins. 

By: Xiao Y, Pollack D, Nieves E, Winchell A, Callaway M, Vigodner M. Anal Biochem. 2014 Nov 29. pii: S0003-2697(14)00527-2. doi: 10.1016/j.ab.2014.11.006. [Epub ahead of print]

Cigarette smoke affects posttranslational modifications and inhibits capacitation-induced changes in human sperm proteins. 

By: Shrivastava V, Marmor H, Chernyak S, Goldstein M, Feliciano M, Vigodner M. Reprod Toxicol. 2014 Jan;43:125-9. doi: 10.1016/j.reprotox.2013.12.001. Epub 2013 Dec 15.


Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. 

By: Vigodner M, Shrivastava V, Gutstein LE, Schneider J, Nieves E, Goldstein M, Feliciano M, Callaway M. Hum Reprod. 2013 Jan;28(1):210-23. doi: 10.1093/humrep/des317. Epub 2012 Oct 17.

 Roles of small ubiquitin-related modifiers in male reproductive function. 

By: Vigodner M. Int Rev Cell Mol Biol. 2011;288:227-59. doi: 10.1016/B978-0-12-386041-5.00006-6. Review.

 SUMO proteins are involved in the stress response during spermatogenesis and are localized to DNA double-strand breaks in germ cells. 

By: Shrivastava V, Pekar M, Grosser E, Im J, Vigodner M. Reproduction. 2010 Jun;139(6):999-1010. doi: 10.1530/REP-09-0492. Epub 2010 Apr 12.

Differential expression patterns of SUMO proteins in HL-60 cancer cell lines support a role for sumoylation in the development of drug resistance. 

By: Vigodner M, Weisburg JH, Shrivastava V, Marmor RA, Fathy J, Skop N. Cell Tissue Res. 2009 May;336(2):277-86. doi: 10.1007/s00441-009-0775-0. Epub 2009 Mar 27.

Sumoylation precedes accumulation of phosphorylated H2AX on sex chromosomes during their meiotic inactivation. 

Vigodner M. Chromosome Res. 2009;17(1):37-45. doi: 10.1007/s10577-008-9006-x. Epub 2009 Jan 21.

SUMO-1, human male germ cell development, and the androgen receptor in the testis of men with normal and abnormal spermatogenesis. 

By: Vigodner M, Ishikawa T, Schlegel PN, Morris PL. Am J Physiol Endocrinol Metab. 2006 May;290(5):E1022-33. Epub 2005 Dec 13.

An experimental study of the effect of two distinct surgical techniques of orchiopexy on spermatogenesis and testicular damage in cryptorchid testes. 

By: Lotan G, Golan R, Efrati Y, Vigodner M, Lewin LM, Shochat L, Klin B. Fertil Steril. 2005 Sep;84(3):749-55.

Testicular expression of small ubiquitin-related modifier-1 (SUMO-1) supports multiple roles in spermatogenesis: silencing of sex chromosomes in spermatocytes, spermatid microtubule nucleation, and nuclear reshaping. 

By: Vigodner M, Morris PL. Dev Biol. 2005 Jun 15;282(2):480-92.

[Evaluation of sperm samples from infertile men by flow cytometry]. 

By: Wald M, Lewin LM, Soffer Y, Oschri Y, Shochat L, Vigodner M, Golan R. Harefuah. 2004 Jan;143(1):22-5, 86. Hebrew.

Evidence for biological rhythm in spermatogenesis in the pubertal hamster (Mesocricetus auratus): a flow cytometric study. 

By: Vigodner M, Lewy H, Lewin LM, Shochat L, Golan R. Life Sci. 2004 Jan 16;74(9):1119-26.

Evaluation of spermatogenesis using flow cytometry and confocal microscopy. 

By: Golan R, Lewin LM, Soffer Y, Lotan G, Shochat L, Vigodner M. Isr Med Assoc J. 2003 Jul;5(7):536. No abstract available.

Use of confocal microscopy for the study of spermatogenesis. 

By: Vigodner M, Lewin LM, Glaser T, Shochat L, Mittelman L, Golan R. Methods Cell Sci. 2002;24(4):169-80.

Evaluation of damage to the testicular cells of golden hamsters caused by experimental cryptorchidism using flow cytometry and confocal microscopy. 

By: Vigodner M, Lewin LM, Shochat L, Oschry I, Lotan G, Kleen B, Golan R. Int J Androl. 2003 Apr;26(2):84-90.

Meiosis in the golden hamster: a confocal microscopy and flow cytometric analysis. 

By: Vigodner M, Lewin LM, Shochat L, Mittelman L, Golan R. Mol Reprod Dev. 2003 Jan;64(1):86-95.

Spermatogenesis in the golden hamster: the role of c-kit. 

By: Vigodner M, Lewin LM, Shochat L, Golan R. Mol Reprod Dev. 2001 Dec;60(4):562-8.

Chromatin condensation during spermiogenesis in the golden hamster (Mesocricetus aureus): a flow cytometric study. 

By: Golan R, Vigodner M, Oschry Y, Shochat L, Lewin LM. Mol Reprod Dev. 2000 May;56(1):105-12.

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