Current Members: Silvia Racedo

Silvia Racedo, Ph.D.

Email: silvia.racedo@einsteinmed.org 

Education:

B. S., M. Sc. Developmental Biology - Facultad de Ciencias Exactas y Naturales - Universidad de Buenos Aires – Argentina.

Ph.D. Reproductive Biology - Facultad de Ciencias Exactas y Naturales - Universidad de Buenos Aires - Argentina and Friedrich-Loeffler-Institute - Germany.

Training - Frontiers in Reproduction - MBL, Woods Hole, MA - USA.

Postdoctoral Fellow - Reproductive Biology - Friedrich-Loeffler-Institute - Germany.

Postdoctoral Fellow - Genetics of Cardiac Development - Department of Genetics - Albert Einstein College of Medicine, NY - USA.

Current position: Research Assistant Professor - Department of Genetics - Albert Einstein College of Medicine, NY - USA.

Research interest:

The main focus of Silvia’s research projects is the functions of genes within the 22q11.2 region such as Tbx1, Crkl and Dgcr8. We explore the potential genetic interaction between these genes, their tissue specificity and their downstream genetic pathways in relation to cardiac development using mouse models.

Previous publications:

1. Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome. Racedo SE, Hasten E, Lin M, Devakanmalai GS, Guo T, Ozbudak EM, Cai CL, Zheng D, Morrow BE. PLoS Genet. 2017 Mar 27;13(3):e1006687. doi: 10.1371/journal.pgen.1006687. eCollection 2017 Mar. PMID: 28346476
2. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. Lopez-Rivera E, Liu YP, Verbitsky M, Anderson BR, Capone VP, Otto EA, Yan Z, Mitrotti A, Martino J, Steers NJ, Fasel DA, Vukojevic K, Deng R, Racedo SE, Liu Q, Werth M, Westland R, Vivante A, Makar GS, Bodria M, Sampson MG, Gillies CE, Vega-Warner V, Maiorana M, Petrey DS, Honig B, Lozanovski VJ, Salomon R, Heidet L, Carpentier W, Gaillard D, Carrea A, Gesualdo L, Cusi D, Izzi C, Scolari F, van Wijk JA, Arapovic A, Saraga-Babic M, Saraga M, Kunac N, Samii A, McDonald-McGinn DM, Crowley TB, Zackai EH, Drozdz D, Miklaszewska M, Tkaczyk M, Sikora P, Szczepanska M, Mizerska-Wasiak M, Krzemien G, Szmigielska A, Zaniew M, Darlow JM, Puri P, Barton D, Casolari E, Furth SL, Warady BA, Gucev Z, Hakonarson H, Flogelova H, Tasic V, Latos-Bielenska A, Materna-Kiryluk A, Allegri L, Wong CS, Drummond IA, D'Agati V, Imamoto A, Barasch JM, Hildebrandt F, Kiryluk K, Lifton RP, Morrow BE, Jeanpierre C, Papaioannou VE, Ghiggeri GM, Gharavi AG, Katsanis N, Sanna-Cherchi S. N Engl J Med. 2017 Feb 23;376(8):742-754. doi: 10.1056/NEJMoa1609009. Epub 2017 Jan 25. PMID: 28121514
3. LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development. Acosta D, Bagchi S, Broin PÓ, Hollern D, Racedo SE, Morrow B, Sellers RS, Greally JM, Golden A, Andrechek E, Wood T, Montagna C.Sci Rep. 2016 Nov 3;6:35810. doi: 10.1038/srep35810. PMID: 27808166
4. Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome. Mlynarski EE, Xie M, Taylor D, Sheridan MB, Guo T, Racedo SE, McDonald-McGinn DM, Chow EW, Vorstman J, Swillen A, Devriendt K, Breckpot J, Digilio MC, Marino B, Dallapiccola B, Philip N, Simon TJ, Roberts AE, Piotrowicz M, Bearden CE, Eliez S, Gothelf D, Coleman K, Kates WR, Devoto M, Zackai E, Heine-Suñer D, Goldmuntz E, Bassett AS, Morrow BE, Emanuel BS; International Chromosome 22q11.2 Consortium. Hum Genet. 2016 Mar;135(3):273-85. doi: 10.1007/s00439-015-1623-9. Epub 2016 Jan 7. PMID: 26742502
5. Copy-Number Variation of the Glucose Transporter Gene SLC2A3 and Congenital Heart Defects in the 22q11.2 Deletion Syndrome. Mlynarski EE, Sheridan MB, Xie M, Guo T, Racedo SE, McDonald-McGinn DM, Gai X, Chow EW, Vorstman J, Swillen A, Devriendt K, Breckpot J, Digilio MC, Marino B, Dallapiccola B, Philip N, Simon TJ, Roberts AE, Piotrowicz M, Bearden CE, Eliez S, Gothelf D, Coleman K, Kates WR, Devoto M, Zackai E, Heine-Suñer D, Shaikh TH, Bassett AS, Goldmuntz E, Morrow BE, Emanuel BS; International Chromosome 22q11.2 Consortium. Am J Hum Genet. 2015 May 7;96(5):753-64. doi: 10.1016/j.ajhg.2015.03.007. Epub 2015 Apr 16. PMID: 25892112
6. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Racedo SE, McDonald-McGinn DM, Chung JH, Goldmuntz E, Zackai E, Emanuel BS, Zhou B, Funke B, Morrow BE. Am J Hum Genet. 2015 Feb 5;96(2):235-44. doi: 10.1016/j.ajhg.2014.12.025. PMID: 25658046
7. Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Kong P, Racedo SE, Macchiarulo S, Hu Z, Carpenter C, Guo T, Wang T, Zheng D, Morrow BE. Hum Mol Genet. 2014 Aug 15;23(16):4215-31. doi: 10.1093/hmg/ddu140. Epub 2014 Apr 4. PMID: 24705356
8. Dynamic changes of the Golgi apparatus during bovine in vitro oocyte maturation. Racedo SE, Rawe VY, Niemann H. Reproduction. 2012 Apr;143(4):439-47. doi: 10.1530/REP-11-0492. Epub 2012 Feb 1. PMID: 22301886
9. Epigenetic modifications and related mRNA expression during bovine oocyte in vitro maturation. Racedo SE, Wrenzycki C, Lepikhov K, Salamone D, Walter J, Niemann H. Reprod Fertil Dev. 2009;21(6):738-48. doi: 10.1071/RD09039. PMID: 19567217
10. Dynamics of microtubules, motor proteins and 20S proteasomes during bovine oocyte IVM. Racedo SE, Branzini MC, Salamone D, Wójcik C, Rawe VY, Niemann H. Reprod Fertil Dev. 2009;21(2):304-12. PMID: 19210921
11. Effects of follicle size and stages of maturation on mRNA expression in bovine in vitro matured oocytes. Racedo SE, Wrenzycki C, Herrmann D, Salamone D, Niemann H. Mol Reprod Dev. 2008 Jan;75(1):17-25. PMID: 17546584