Albert
              Einstein College of Medicine

                     Baker Lab
             Albert Einstein College of Medicine, Bronx, N.Y.



Baker, NE, Brown, NL. (2018) All in the family: bHLH genes and neuronal diversity. Dev 145:9. [Abstract]

Li, K, Baler, N.E. (2018) Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners. Elife pii: e33967. [Abstract]

Kale, A., Ji, Z., Kiparaki,  M., Blanco, J., Rimesso, G., Flibotte, S., and Baker, N.E. (2018) Ribosomal protein S12e has a distincy function in cell competition. Dev Cell 44:42-55. [Abstract]

Bhattacharya, A., Li, K., Quiquand, M., Rimesso, G., and Baker, N.E. (2017) Mechanisms of cell competition emerging form Drosophila studies. Dev. Bio 48:40-46. [Abstract]

Baker, N.E. (2017) Patterning the eye: a role for the cell cycle? Dev. Bio 430:263-5. [Abstract]

Baker, N.E. (2017) Mechanisms of cell competition emerging form Drosophila studies. Dev. Bio 48:40-46. [Abstract]

Lee, C.-H., Rimesso,G., Reynolds, D., Cai, J. and Baker, N.E. (2016) Whole genome sequencing and iPLEX MassARRAY genotyping map an EMS-induced mutation affecting cell competition in Drosophila melanogaster. G3(Besthesada) 6:3207-3217.  [Abstract]

Baker, N.E and Kale, A. (2016) Ribosomal protein mutation: apoptosis, cell competition and cancer. Molecular Cellular Oncology 3(1):e1029065. [Abstract]

Kale A., Rimesso G, and Baker NE.  (2016) Local cell death changes the orientation of cell division in the developing Drosophila wing imaginal disc without using Fat or Dachsous as orienting signals. PLoS One 11:e0167637. [Abstract]

Wang LH, Baker NE. (2015) E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease. Dev Cell 35(3): 269-280. [Abstract]

Baker NE, Kale A. (2015) Mutations in ribosomal proteins: apoptosis, cell competition and cancer. Molecular & Cellular Oncology [in press]

Kale A, Li W, Lee CH, Baker NE. (2015) Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica. Cell Death Differ. 22(8):1300-1312. [Abstract]

Wang LH, Baker NE. (2015) Salvador-Warts-Hippo Pathway in a Developmental Checkpoint Monitoring Helix-Loop-Helix Proteins. Dev Cell 32(2):191-202.[Abstract]

Fullard JF, Baker NE. (2015) Signaling by the Engulfment Receptor Draper: A Screen in Drosophila melanogaster Implicates Cytoskeletal Regulators, Jun N-Terminal Kinase, and Yorkie. Genetics 199(1):117-34. [Abstract]

Baker NE, Jenny A. (2014) Metabolism and the other fat: a protocadherin in mitochondria. Cell 158(6):1240-1.[Abstract]

Baker NE, Li K, Quiquand M, Ruggiero R, Wang LH. (2014) Eye development. Methods : a companion to Methods in enzymology. 68(1):252-9.[Abstract]

Baker NE. (2013) Developmental Regulation of Nucleolus Size during Drosophila Eye Differentiation. PLoS One. 2013;8(3):e58266.[Abstract]

Ruggiero R,  Kale, A.,  Thomas,B., and  Baker, N.E. (2012) Roughex and Anaphase promoting complex maintain cell cycle exit to prevent cytokinetic and axonal defects in Drosophila photoreceptor neurons. PLoS Genetics,  2012;8(11):e1003049.[Abstract

Bhattacharya A, Baker NE. (2012) The Role of the bHLH Protein Hairy in Morphogenetic Furrow Progression in the Developing Drosophila Eye. PLoS One. 2012;7(10)[Abstract]

Bhattacharya, A. and Baker, N.E. (2011) A network of broadly-expressed HLH genes regulates tissue-specific cell fates.  Cell,147(4):881-92.[Abstract]

Lubensky, D.K., Penninton, M.W., Shraiman, B., and Baker, N.E. (2011) A dynamical model of ommatidial crystal formation.  Proc Natl Acad Sci, 108: 11145-11150.[Abstract]

Baker, N.E., and Firth, L.C.  (2011)  Retinal Determination Genes function along with cell-cell signals to regulate Drosophila eye development: examples of multi-layered regulation by Master Regulators.  Bioessays, 33: 538-546. [Abstract]

Baker, N.E.  (2011) Proximodistal patterning in the Drosophila leg:  models and mutations. Genetics,187 1003-1010.[Abstract]

Baker, N.E. (2011)  Cell competition.  Curr Biol 21:  R11-15.[Abstract]

Li W, Kale A, Baker NE.(2009) Oriented cell division as a response to cell death and cell competition.Curr Biol. 2009 Nov 17;19(21):1821-6. [Abstract]

Baker NE, Bhattacharya A, Firth LC.
(2009) Regulation of Hh signal transduction as Drosophila eye differentiation progresses.Dev Biol. 2009 Nov 15;335(2):356-66.[Abstract]

Fullard JF, Kale A, Baker NE. (2009) Clearance of apoptotic corpses.Apoptosis. 2009 Aug;14(8):1029-37.[Abstract]

Firth LC, Baker NE. (2009) Retinal determination genes as targets and possible effectors of extracellular signals.Dev Biol. 2009 Mar 15;327(2):366-75. [Abstract]

Bhattacharya A, Baker NE. (2009) The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye. Dev Biol. 2009 Mar 15;327(2):288-300.[Abstract]

Wei Li and Nicholas Baker. (2008) Cell competition and its possible relation to cancer.cancer research Jul 15;68(14):5505-7. [Abstract]

Pei Z. and Baker N.E. (2008) Competition between Delta and the Abruptex domain of Notch. BMC Dev Biol., 2008 Jan 21;8(1):4 [Abstract]

Wei Li and Nicholas Baker. (2007) The Active Role of Corpse Engulfment Pathways During Cell Competition. FLY,volume 1 | issue 5 September/October 2007 Pages: 274 - 278 [Abstract]

Tyler DM, Li W, Zhuo N, Pellock B, Baker NE. (2007) Genes affecting cell competition in Drosophila. Genetics. 2007 Feb;175(2):643-57 [Abstract]

Li, W. and Baker, N.E. (2007)  Cell competition depends on cell engulfment to induce apoptosis of neighboring cells.  Cell,2007 Jun 15;129(6):1215-25.[Abstract]

Firth, L.C., and Baker, N.E. (2007) Spitz from the retina regulates genes transcribed in the Second Mitotic Wave,  peripodial epithelium,  glia and plasmatocytes of the Drosophila eye imaginal disc.  Dev. Biol.,2007 Jul 15;307(2):521-38 [Abstract] {RNA in situ hybridization patterns of genes involved in eye imaginal disc}

Baker, N.E.  (2007)  Patterning signals and proliferation in Drosophila imaginal discs.Curr Opin Genet Dev., 2007 Aug;17(4):287-93 [Abstract]

Tyler, D. and Baker, N.E. (2007)  Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways.  Dev. Biol., 305, 187-201.[Abstract]

Yang, L. and Baker, N.E. (2006) Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye. BMC Dev Biol 6, 8. [Abstract]

Firth, L.C., Li, W., Zhang, H., and Baker, N.E. (2006) Analyses of RAS regulation of eye development in Drosophila melanogaster. Meth. Enzymol.,407(56), 711-721.[Abstract]

Sidyelyeva, G., Baker, N.E. and Fricker, L.D. (2006) Characterization of the molecular basis of the drosophila mutations in carboxypeptidase D. Effect on enzyme activity and expression. J Biol Chem 281, 13844-13852. [Abstract]

Firth, L.C. and Baker, N.E. (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8, 541-551. [Abstract]

Baker, N.E. (2004) Atonal points the way- protein-protein interactions and developmental biology. Dev Cell 7, 632-634. [Abstract]

Li, Y. and Baker, N.E. (2004) The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila. BMC Dev Biol 4, 5. [Abstract]

Shi, W., Stampas, A., Zapata, C. and Baker, N.E. (2003) The pineapple eye gene is required for survival of Drosophila imaginal disc cells. Genetics 165, 1869-1879. [Abstract]

Firth, L.C. and Baker, N.E. (2003) EGF receptor signaling: a prickly proposition. Curr Biol 13, R773-774. [Abstract]

Fu, W. and Baker, N.E. (2003) Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development. Development 130, 5229-5239. [Abstract]

Li, Y., Lei, L., Irvine, K.D. and Baker, N.E. (2003) Notch activity in neural cells triggered by a mutant allele with altered glycosylation. Development 130, 2829-2840. [Abstract]

Li, Y., Fetchko, M., Lai, Z.C. and Baker, N.E. (2003) Scabrous and Gp150 are endosomal proteins that regulate Notch activity. Development 130, 2819-2827. [Abstract]

Yang, L. and Baker, N.E. (2003) Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev Cell 4, 359-369. [Abstract]

Tyler, D. and Baker, N.E. (2003) Size isn't everything. Bioessays 25, 5-8. [Abstract]

Yu, S.Y., Yoo, S.J., Yang, L., Zapata, C., Srinivasan, A., Hay, B.A. and Baker, N.E. (2002) A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development 129, 3269-3278. [Abstract]

Baker, N.E. (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol 12, 499-507. [Abstract]

Baker, N.E. (2001) Master regulatory genes; telling them what to do. Bioessays 23, 763-766. [Abstract]

Li, Y. and Baker, N.E. (2001) Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye. Curr Biol 11, 330-338. [Abstract]

Baker, N.E. and Yu, S.Y. (2001) The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell 104, 699-708. [Abstract]

Yang, L. and Baker, N.E. (2001) Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina. Development 128, 1183-1191. [Abstract]

Lee, E.C., Yu, S.Y. and Baker, N.E. (2000) The scabrous protein can act as an extracellular antagonist of notch signaling in the Drosophila wing. Curr Biol 10, 931-934. [Abstract]

Baker, N.E. (2000) Notch signaling in the nervous system. Pieces still missing from the puzzle. Bioessays 22, 264-273. [Abstract]

Lesokhin, A.M., Yu, S.Y., Katz, J. and Baker, N.E. (1999) Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. Dev Biol 205, 129-144. [Abstract]

Lee, E.C., Yu, S.Y., Hu, X., Mlodzik, M. and Baker, N.E. (1998) Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains. Genetics 150, 663-673. [Abstract]

Baker, N.E. and Yu, S.Y. (1998) The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose. Mech Dev 74, 3-14. [Abstract]

Baker, N.E. and Yu, S.Y. (1997) Proneural function of neurogenic genes in the developing Drosophila eye. Curr Biol 7, 122-132. [Abstract]

Baker, N.E., Yu, S. and Han, D. (1996) Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr Biol 6, 1290-1301. [Abstract]

Lee, E.C. and Baker, N.E. (1996) gp300sca is not a high affinity Notch ligand. Biochem Biophys Res Commun 225, 720-725. [Abstract]

Lee, E.C., Hu, X., Yu, S.Y. and Baker, N.E. (1996) The scabrous gene encodes a secreted glycoprotein dimer and regulates proneural development in Drosophila eyes. Mol Cell Biol 16, 1179-1188. [Abstract]

Hu, X., Lee, E.C. and Baker, N.E. (1995) Molecular analysis of scabrous mutant alleles from Drosophila melanogaster indicates a secreted protein with two functional domains. Genetics 141, 607-617. [Abstract]

Baker, N.E. and Zitron, A.E. (1995) Drosophila eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous. Mech Dev 49, 173-189. [Abstract]

Baker NE, Moses K, Nakahara D, Ellis MC, Carthew RW, Rubin GM. (1992) Mutations on the second chromosome affecting the Drosophila eye.J Neurogenet. May;8(2):85-100.

Baker NE, Rubin GM. (1992) Ellipse mutations in the Drosophila homologue of the EGF receptor affect pattern formation, cell division, and cell death in eye imaginal discs. Dev Biol. 1992 Apr;150(2):381-96.

Baker NE, Mlodzik M, Rubin GM. (1990) Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous.Science. Dec 7;250(4986):1370-7.

Mlodzik M, Baker NE, Rubin GM. (1990) Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila.Genes Dev.Nov;4(11):1848-61.

Baker NE, Rubin GM. (1989) Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor.Nature. Jul 13;340(6229):150-3.

Baker NE. (1988) Localization of transcripts from the wingless gene in whole Drosophila embryos.Development. Jun;103(2):289-98.

Martizez Arias A, Baker NE, Ingham PW. (1988) Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo.Development. May;103(1):157-70.

Baker NE. (1988) Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation. Development. Mar;102(3):489-97.

Ingham PW, Baker NE, Martinez-Arias A. (1988) Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped.Nature. Jan 7;331(6151):73-5.

Baker NE. (1988) Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila.Dev Biol. Jan;125(1):96-108.

Baker NE. (1987) Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos. EMBO J. Jun;6(6):1765-1773.