RNA in situ hybridization patterns of genes downregulated in GMR > sSpi vs. GMR > RasV12
| Gene | SLR | Expression pattern | Function/homology | |
|---|---|---|---|---|
|
Disc proper (27)
|
||||
| SoxN | − 5.65 | Differentiating photoreceptors posterior to MF | Nervous system development | |
| lz | − 4.06 | Subset of cells posterior to the morphogenetic MF | Eye cell fate specification and differentiation | |
| Spn43A | − 3.67 | Cells anterior to the MF and in posterior inter-ommatidial cells | Serine-type endopeptidase inhibitor activity | |
| CG15630 | − 3.49 | Subgroups of cells in 3/4 columns posterior to MF | Cell adhesion | |
| SP1029 | − 3.45 | Band anterior to the MF; inner tarsal ring of leg imaginal disc | Proteolysis | |
| CG31676 | − 3.22 | Retinal basal glial cells | – | |
| Fas2 | − 2.91 | Differentiating photoreceptors | Cell adhesion; axonal fasciculation; synaptic plasticity | |
| B-H1 | − 2.87 | Subset of photoreceptors and accessory cells | Photoreceptors R1 and R6, pigment and lens cell differentiation | |
| thisbe | − 2.81 | Individual differentiating cells posterior to MF | FGFR ligand. FGFR signaling in mesoderm, hindgut and heart | |
| CG31291 | − 2.71 | Ubiquitous | – | |
| Pde8 | − 2.37 | Band just anterior to MF; PE; plasmatocytes; lumen and nuclei of salivary glands. Nuclei of fat body | Signal transduction; cyclic nucleotide metabolism; mesoderm development | |
| Klg | − 2.14 | Three rows of cells ahead of MF; ommatidial cluster; refines to R7 | R7 photoreceptor cell fate commitment and differentiation | |
| CG13966 | − 2.03 | Band anterior to MF | – | |
| ato | − 1.95 | Stripe anterior to MF, refines to R8 cells only | R8 cell specification | |
| GM130 | − 1.92 | Anterior to MF | Golgi organization and biogenesis; mitosis; protein targeting | |
| trn | − 1.91 | Band of cells just anterior to MF refining to clusters of cells and a subset of differentiating cells | Target of Egfr/PntP1 signaling in embryonic ventral ectoderm | |
| Obp44a | − 1.84 | Photoreceptor axons as exiting optic stalk and optic lobe | – | |
| CG8502 | − 1.71 | Individual cells near posterior edge of MF for 2/3 columns; eye, leg and wing PE; plasmatocytes | Structural constituent of larval cuticle | |
| CG5653 | − 1.71 | Ubiquitous | – | |
| CG15911 | − 1.69 | Anterior D/V margins of eye disc; plasmatocytes | – | |
| E(spl) m2 | − 1.68 | Clusters of cells in the MF region | Notch signaling pathway | |
| CAP | − 1.64 | Expressed within MF | MAPKKK cascade; cytoskeleton organization and biogenesis | |
| CG5929 | − 1.61 | Broad band anterior to MF | Nucleic acid metabolism; RNA-dependent transcription | |
| Ppn | − 1.58 | Diffusely expressed in eye imaginal disc | Component of the ECM; metallopeptidase activity | |
| Traf1 | − 1.56 | SMW cells and clusters within MF; ZNP cells in the wing | In vivo regulator of JNK pathway | |
| Brd | − 1.5 | Expressed within MF | Sensory organ precursor cell fate determination; Notch pathway | |
| Bib | − 1.5 | Required during R8 specification | Lateral inhibition of R8 specification; embryonic neurogenesis | |
| arc | − 1.4 | Clusters along MF | Adheren junction associated protein required for eye development | |
| ss | − 1.34 | MF; expressed in all other imaginal discs | Antennal morphogenesis; transcription factor | |
|
Peripodial
epithelium (12)
|
||||
| Cyp4e2 | − 3.19 | PE of the eye/antennal and wing imaginal discs | Electron transport; steroid metabolism | |
| Osiris 23 | − 3.16 | PE of the eye and leg imaginal discs | – | |
| CG11073 | − 2.59 | PE of the eye, leg and wing imaginal discs | – | |
| CG3893 | − 2.56 | PE of the eye imaginal disc | – | |
| Pde8 | − 2.37 | Band just anterior to MF; PE; plasmatocytes; lumen and nuclei of salivary glands; nuclei of fat body | Signal transduction; cyclic nucleotide metabolism; mesoderm development | |
| beat-Ic | − 2.33 | Peripodial cell's nucleoli | Axon choice point recognition; cell adhesion; defasciculation | |
| wbl | − 1.71 | PE of the eye imaginal disc | Exocytosis; protein-Golgi targeting | |
| CG8502 | − 1.71 | Individual cells posterior to MF for 2/3 columns; eye, leg and wing PE; plasmatocytes | Structural constituent of larval cuticle | |
| CG13203 | − 1.7 | PE of the eye imaginal disc; plasmatocytes | – | |
| CG4408 | − 1.7 | PE of the eye imaginal disc | Proteolysis: metallocarboxypeptidase activity | |
| CG2657 | − 1.5 | PE of the eye and wing discs; cells in wing disc | Transport: glutamate-gated ion channel activity | |
| CG15370 | − 1.34 | PE of the eye imaginal disc | – | |
|
Glia (1)
|
||||
| CG31676 | − 3.22 | Retinal basal glial cells | – | |
|
Plasmatocytes (10)
|
||||
| Pde8 | − 2.37 | Band just anterior to MF; peripodial cells; plasmatocytes; lumen and nuclei of salivary glands; nuclei of fat body | Signal transduction; cyclic nucleotide metabolism; mesoderm development | |
| twe | − 1.85 | Plasmatocytes | Protein tyrosine phosphatase activity; mitosis | |
| CG12508 | − 1.73 | Plasmatocytes | – | |
| CG8502 | − 1.71 | Individual cells posterior to MF for 2/3 columns; eye, leg and wing peripodial cells; plasmatocytes | Structural constituent of larval cuticle | |
| CG13203 | − 1.7 | PE of the eye imaginal disc; plasmatocytes | – | |
| CG15911 | − 1.69 | Anterior D/V margins of eye disc; plasmatocytes | – | |
| PGRP-SC2 | − 1.55 | Wing pleurites and plasmatocytes | Peptidoglycan recognition molecule | |
| Smg1 | − 1.44 | Plasmatocytes | Nonsense-mediated decay; protein kinase activity | |
| robl62A | − 1.44 | Plasmatocytes | Microtubule-based movement; dynein complex; ATPase activity | |
| CG18547 | − 1.39 | Plasmatocytes | Oxidoreductase activity | |
|
Other imaginal
discs or tissues (5)
|
||||
| Ugt86Di | − 3.58 | Expressed in the wing disc | – | |
| Obp44a | − 1.84 | Photoreceptor axons as exiting optic stalk and optic lobe | – | |
| CG8483 | − 1.63 | Expressed in the wing disc | – | |
| PGRP-SC2 | − 1.55 | Wing plurites and plasmatocytes | – | |
| ss | − 1.34 | MF; expressed in all other imaginal discs | Antennal morphogenesis; transcription factor | |