Representative Publications
* Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4. Immunity 41(2): 296-310 (2014)
** Dvorak Z et al (40 authors), Mani S*. Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry. EMBO Molecular Medicine (Cover Page Citation) 12(4):e11621(2020)
** Dvorak Z, Sokol H, Mani S. Drug Mimicry: Promiscuous Receptors PXR and AhR, and Microbial Metabolite Interactions in the Intestine. Trends Pharm Sci (Cover Page Citation) 41(12): 900-908 (2020)
*** Serger E et al (primary work from the Giovanni lab, Imperial College, London). The gut metabolite indole-3 propionate promotes nerve regeneration and repair. Nature Jun 22 doi:10.1038/s41586-022-04884-x (online ahead of print 2022)
$ De A, Chen W, Li H, Wright JR, Lamendella R, Lukin DJ, Szymczak WA, Sun K, Kelly L, Ghosh S, Kearns DB, He Z, Jobin C, Luo X, Byju A, Chatterjee S, San Yeoh B, Vijay-Kumar M, Tang JX, Prajapati M, Bartnikas TB, Mani S. Bacterial Swarmers Enriched During Intestinal Stress Ameliorate Damage. Gastroenterology 161(1):211-224. doi: 10.1053/j.gastro.2021.03.017 ( 2021)
$$ Chen W, Mani N, Karani H, Li H, Mani S, Tang JX. Confinement discerns swarmers from planktonic bacteria. Elife 10:e64176 (2021)
Most Recent: Ondrová K, Zůvalová I, Vyhlídalová B, Krasulová K, Miková E, Vrzal R, Nádvorník P, Nepal B, Kortagere S, Kopečná M, Kopečný D, Šebela M, Rastinejad F, Pu H, Soural M, Rolfes KM, Haarmann-Stemmann T, Li H, Mani S, Dvořák Z. Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice. Nat Commun. 2023 May 11;14(1):2728. doi: 10.1038/s41467-023-38478-6. PMID: 37169746; PMCID: PMC10174618.