Department of Molecular Pharmacology

Hormone Action and Signal Transduction

COURSE LEADERS: Drs. Jonathan M. Backer and Charles Rubin

CREDITS/CLASS MEETINGS: 3 semester hours; ~ 40 lectures (60 minutes).

PREREQUISITE BACKGROUND: Intermediate Biochemistry is desirable, but not absolutely

necessary; graduate level understanding of protein structure and function, DNA structure & function also desirable.

SUITABILITY FOR 1ST YEAR STUDENTS: Yes, with appropriate background. If uncertain, see Dr. Rubin or Dr. Backer for interview.

COURSE DESCRIPTION: This course considers two fundamental aspects of biological regulation in experimental and theoretical detail: 1) The biochemical and molecular basis for the interaction between hormones and receptors; and 2) the mechanisms by which hormone-receptor complexes control cell metabolism, motility, proliferation, and the expression of specific genes. A series of hormone/receptor systems is discussed to provide current concepts of the diverse mechanisms by which different classes of hormones exert their actions. A partial list of topics includes: growth factors and their receptors and relationships to oncogene products; catecholamine-regulated adenylate cyclase with a focus on the role of a family of GTP-binding proteins as mediators of hormone action; regulation of intracellular calcium and calcium-induced signaling the enzymatic, structural and functional properties of cAMP-dependent, calmodulin- activated and calcium- phospholipid activated protein kinases; phosphoinositide kinases and their downstream effectors; small GTPases and their role in mitogenic signaling and cytoskeletal regulation; signaling by nonreceptor tyrosine kinases; the progesterone and glucocorticoid receptors and the central roles of steroid receptor-ligand complexes in controlling gene transcription; TGF signaling in development.


LEVELS: Sue Golding Graduate Division


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