Core Director: Matthew K. Abramowitz, M.D., M.S.
Technician: Robin Sgueglia
Biomarkers are playing an increasingly important role in clinical and translational research, especially as we move toward an era of personalized medicine in both the prevention and treatment of disease. The Biomarker Analytic Research Core (BARC) — the central laboratory for the ICTR, DRC and the Biorepository — provides sophisticated tools and expertise for Einstein and Montefiore investigators from the initial study planning stage through analysis and data output.
Services
Facility services include:
- State-of-the-art mass spectrometry analysis, including stable isotopes, as well as research-grade determination of lipids, and metabolic markers for a variety of human subjects and animal model projects.
- High-throughput robotics for semi-automated high-quality sample preparation and analysis by immunoassay and liquid chromatography–mass spectrometry (LC/MS).
- Support for novel developmental projects featuring applications of LC/MS and two-site bead-based assays.
- Research quality analysis of metabolites for human and animal samples using an Olympus AU400 autoanalyzer.
- Advanced training in analytical chemistry.
In addition to its isotope dilution LC/MS assays, BARC has already validated and made available quantitative measurement of 25(OH)2 vitamin D, androstenedione and testosterone via LC/MS. Other dual-use assays for steroids are under development, including ultrahigh sensitivity salivary cortisol, estradiol, and progesterone which will support both clinical care and research use. BARC also offers a novel method for LC/MS measurement of C-peptide, and is currently the reference lab for an ongoing clinical trial measuring insulin secretion.
All samples processed are labeled with barcoded cryolabels for easy identification. Records of samples and data are seamlessly integrated and tracked, and are remotely accessible via a secure research database.
Service Requests
Before bringing samples to the facility, please visit our iLab page which will provide you with pricing for all available services.
Available Assays
Chemistries
Alanine Aminotransferase (ALT)
Albumin
Alkaline Phosphatase (ALP)
Apolipoprotein A1
Apolipoprotein B
Aspartate Aminotransferase (AST)
Beta-Hydroxybutyrate, Serum
Bicarbonate
Bilirubin, Direct
Bilirubin, Total
Calcium, Serum
Calcium, Urine
Chloride, Serum
Chloride, Urine
Cholesterol
Creatinine, Serum
Creatinine, Urine
Cystatin C
D-Dimer
Gamma-Glutamyl Transpeptidase
Glucose
Glycerol, Free
HDL Cholesterol, Direct
High Sensitivity CRP
Lactate
Lactate Dehydrogenase
LDL Cholesterol, Calculated
LDL Cholesterol, Direct
Magnesium
Microalbumin
Microalbumin/Creatinine ratio, Urine
Non-Esterified Free Fatty Acids, Total
Phosphorous, Serum
Phosphorous, Urine
Potassium, Serum
Potassium, Urine
Prealbumin
Protein, Total
Sodium, Serum
Sodium, Urine
Triglycerides
Urea Nitrogen, Blood
Urea Nitrogen, Urine
RIA/ELISA
A2 Macroglobulin, Human ELISA
Adiponectin, Human RIA
Adiponectin, HMW Human ELISA
Adiponectin, Mouse ELISA
BDNF, Human ELISA
Bone Trap, Human ELISA
C-Peptide, Human ELISA
C-Peptide, Human RIA
C-Peptide, Rat ELISA
CK 18 (M65), Human ELISA
CK 18 Frag (M30), Human ELISA
Corticosterone ELISA
Cortisol ELISA
DHEAS, Human ELISA
E-Selectin, Human ELISA
Estrone, Human ELISA
FGF-21, Human ELISA
FGF-23 (C-Term), Human ELISA
FGF-23 (Intact), Human ELISA
Follicle Stimlating Hormone, Human ELISA
Free Testosterone, Human ELISA
Ghrelin (Total), RIA
GLP-1 (Total), Human ELISA
Glucagon 10ul ELISA
Glucagon ELISA
Growth Hormone, Human ELISA
Growth Hormone, Rat/Mouse ELISA
Hyaluronic Acid, Human ELISA
H. pylori IgG, Human ELISA
ICAM, Human ELISA
IGF-1, Human ELISA
IGF-1, Rat/Mouse ELISA
IGF-2, Human ELISA
IGFBP-1, Human ELISA
IGFBP-3, Human ELISA
IL-1 beta, high sensitivity, Human ELISA
IL-10, Human ELISA
IL-6, Human Chemiluminescence ELISA
IL-8, Human ELISA
Insulin, Human ELISA
Insulin, Human Specific RIA
Insulin, Mouse ELISA
RIA/ELISA
Insulin, Mouse US ELISA
Insulin, Rat ELISA
Insulin, Rodent Chemiluminescence ELISA
Leptin, Human ELISA
Leptin, Human RIA
Leptin, Mouse ELISA
Leptin, Rat ELISA
LTB4, Human ELISA
Lutenizing Hormone, Human ELISA
NGAL, Human ELISA
Osteoprotegerin, Human ELISA
PAI-1, Human ELISA
Pancreatic Polypeptide, Human ELISA
Pepsinogen I, Human ELISA
Pepsinogen II, Human ELISA
PLA2G7, Human ELISA
Proinsulin, Human RIA
Proinsulin, Mouse ELISA
PYY (3-36) Specific, Human RIA
RBP4, Human ELISA
Resistin, Human ELISA
Resistin, Mouse ELISA
Sex Hormone Binding Globulin, Human ELISA
sRage, Human ELISA
Testosterone, Human ELISA
TIMP-1, Human ELISA
Tissue Factor, Human ELISA
TNF-alpha, Human ELISA
TNF-alpha, Rat ELISA
VEGF, Human ELISA
Vitamin D Binding Protein, Human ELISA
YKL-40, Human ELISA