In“valv”uable Insights — Dr. Bin Zhou has been awarded $2.4 million over four years by the National Heart, Lung, and Blood Institute in order to study the genetic pathways that regulate aortic valve biology and that mediate calcific aortic valve stenosis (CAVS). A complex syndrome involving multiple cellular processes, CAVS is the most common disease to require surgical valve replacement. Using mouse models to study CAVS and its cellular and molecular mechanisms, Dr. Zhou is seeking critical information concerning the origins and effects of CAVS, with the goal of developing new therapeutic and preventive strategies for this devastating form of heart disease. Dr. Zhou is associate professor of genetics, of pediatrics and of medicine (cardiology). Drs. Bingruo Wu (genetics), Deyou Zheng (neurology), and Richard Kitsis (medicine) are co-investigators on this project.
Posted on: Tuesday, August 21, 2012