![Autophagy & the Immune Response]()
The National Institute of Allergy and Infectious Diseases has awarded Fernando Macian-Juan, M.D., Ph.D., a five-year, $2-million grant to study how chaperone mediated autophagy (CMA) in T cells regulates the cells’ function. CMA is a degradation system that cells use to break down and recycle their proteins. Dr. Macian and his team have recently found that activating antigen receptors on CD4+ T cells triggers a signaling pathway that turns on CMA, which then regulates CD4+ T- cell function. Understanding how CMA modulates CD4+ T cell function could lead to strategies for controlling adaptive immune responses. Dr. Macian is associate professor of pathology.
Posted on: Tuesday, June 28, 2016