![Reducing Radiation Injury]()
Radiation exposure from nuclear accidents or terrorism can cause mass casualties and poses a serious ongoing threat. Radiation-induced vascular injury (RIVI) is a critical component of the multi-organ failure caused by acute radiation exposure syndrome. RIVI can lead to blood problems such as anemia and thrombocytopenia and damage critical organs, especially intestines and lungs. The National Institutes of Health has awarded Chandan Guha M.B.B.S., Ph.D., a five-year, $2.3 million grant to develop measures to prevent RIVI. In collaboration with Janssen Pharmaceuticals, Inc., Dr. Guha and colleagues will test whether the drug Thrombopoietin Mimetic (TPOm) can protect against vascular injuries caused by radiation. The team will first evaluate TPOm in mice—an effort that will require developing imaging techniques to assess the extent radiation induced normal tissue injury. Dr. Guha is director of the Einstein Institute for Onco-physics, professor and vice chair of radiation oncology, as well as professor of urology and of pathology at Einstein and Montefiore. (1U01AI133608-01)
Posted on: Friday, August 04, 2017