![Studying the Dynamics of Cell Growth]()
Dysregulated cell growth leads to cancer and many other diseases. In many cases, a mutation to the p53 tumor suppressor gene triggers aberrant cell growth. The National Institute of General Medical Sciences has awarded Robert Coleman, Ph.D., a four-year, $1.3 million grant to study the interplay between p53, chromatin (the complex of DNA and protein that forms chromosomes) and transcriptional bursting in single cells (when transcription from DNA to RNA occurs in bursts or pulses). Dr. Coleman and colleagues will use a single molecule live cell imaging system to directly visualize the p53 protein and the molecules it recruits to tightly regulate DNA repair, DNA replication and cell division. Insights into how this system is coordinated may lead to therapies to restore normal cellular growth in cancer and other diseases. Dr. Coleman is an assistant professor of anatomy and structural biology. (1R01GM126045-01A1)
Posted on: Monday, April 30, 2018