COVID-19: Read the latest research news and education updates

Einstein Community: Review policies & guidelines and view dashboard.

  • Library
  • Intranet
Albert Einstein College of Medicine
  • About
  • Education
  • Research
  • Departments & Centers
Giving
Search
Menu
Montefiore Health System
  • Faculty Directory
  • Research Connections
  • Faculty Directory
  • Research Connections
Information For
  • Alumni
  • Donors
  • Faculty
  • Postdocs
  • Students (Prospective, Current)
  • Visitors
Quick Links
  • About
  • Administration
  • Departments & Centers
  • Directory
  • Education & Admissions
  • Events
  • Find Faculty
  • Giving
  • Health
  • Intranet
  • Library
  • Research
  • Webmail
News & Media
  • Newsroom
  • Blog
  • Einstein in the News
  • Expert List for Media
  • Features
  • Magazine
  • Multimedia
  • News Releases
  • Research Briefs
  • Social Media Hub

Faculty Profile

  • Home
  • Faculty Directory
  • Jean M. Hebert, Ph.D.

Jean M. Hebert, Ph.D.

Jean M. Hebert

Professor, Dominick P. Purpura Department of Neuroscience

Professor, Department of Genetics

Area of Research: Devising methods of cell and tissue replacement for the adult neocortex to repair damage or age-related degeneration.

Contact Information

718.430.3494jean.hebert@einsteinmed.edu

Albert Einstein College of Medicine
Rose F. Kennedy Center

1410 Pelham Parkway South, Room 237
Bronx, NY 10461

Research ProfilesPubMed Portal

More Resources: Lab website

Is this your profile? Edit profile

Professional Interests

 

Regenerating the neocortex.

The neocortex is the part of our brain that performs our highest cognitive functions. In recent years, the mechanisms underlying how stem cells in the embryo generate the neocortex have become better understood. Armed with this knowledge, the Hébert Lab is developing stem cell transplantation approaches to repair or replace adult neocortical tissue after age-related degeneration.

The lab’s projects fall into two groups. In the first, we use the mouse neocortex as a platform for testing the ability of multi-cell type grafts (increasingly resembling normal neocortex) to integrate with host tissue. In the second, we are testing the ability of genetically engineered microglia that disperse throughout the adult neocortex to bolster neocortical function.

These are highly collaborative projects requiring multidisciplinary methods, which include molecular genetics, human embryonic stem cell biology, transcriptomics, surgery, electrophysiology, live brain imaging, and behavioral tests, among others. Thus the Hébert Lab offers its members excellent opportunities for acquiring diverse and cutting-edge skill sets in an up-and-coming research area.

LAB WEBSITE: https://hebertlab.einsteinmedneuroscience.org

POSITIONS AVAILABLE: The Hébert lab is seeking to add qualified personnel to its team, including a Research Assistant and several Postdocs starting June 2021. Please inquire if interested.

ALTERNATE CONTACT: tweet me @Replacing_Aging


Selected Publications

Krzyspiak J, Khodakhah K, Hébert JM. (2022). Potential variables for improved reproducibility of neuronal cell grafts at stroke sites. Cells 11:1656.

Krzyspiak J, Yan J, Ghosh H, Galinski B, Lituma P, Alvina K, Quezada A, Kee S, Grońska-Pęski M, Tai YD, McDermott K, Gonçalves JT, Zukin RS, Weiser DA, Castillo P, Khodakhah K, Hébert JM. (2021). Donor-derived vasculature is required to support neocortical cell grafts after stroke. Stem Cell Res. 59:102642. PMID: 34971934..

Mohammad S, Bellampalli R, Ghosh V, Krishna S, Dwivedi A, Nruthyathi, Sahasrabuddhe, V, Cheramangalam R, Radha S, Ceribelli M, Reizis B, Hébert JM, Ghosh H (2021). Adult neural stem cells have latent inflammatory potential, kept in check by Tcf4. Science Advances 7:eabf5606. PMID: 34020954 PMCID: PMC8139598.

 

Gronska-Peski M, Gonçalves JT, Hébert JM. (2021). Enriched environment acts through FGFRs to increase adult hippocampal neurogenesis. J. Neurosci. 41:2899-2910. PMID 33637561 PMCID: PMC8018882

 

Gronska-Peski M, Mowrey W, Hébert JM. (2021). FGFR regulation of dendrite elaboration in adult-born granule cells depends on intracellular mediator and proximity to the soma. Neuroscience 453:148-167. PMID 33246055

 

Galinski B, Luxemburg M, Landesman Y, Pawel B, Master SR, Freeman K, Hébert JM, Weiser D. (2021). IkB modulates synergy between selinexor, an XPO1 inhibitor, and bortezomib in neuroblastoma. Translational Oncology 14:101114. PMID: 33975179 PMCID: PMC8131731

 

Gronska-Peski M, Schachner M, Hébert JM. (2020). L1cam curbs the differentiation of adult-born hippocampal neurons. Stem Cell Research 48:101999. PMID 32971459.

 

Barbar L, Jain T, Zimmer M, Kruglikov I, Sadick J, Wang M, Kalpana K, Rose I, Burstein SR, Rusielewicz T, Nijsure M, Croft G, Zhang B, Nobuta H, Hébert JM, Liddelow S, Fossati V. (2020). CD49f is a novel marker of functional and reactive human iPSC-derived astrocytes. Neuron 107:436-453. PMID 32485136.

 

Blackwood CA, Bailetti A, Nandi S, Gridley T, Hébert JM. (2020). Notch dosage: Jagged1 haploinsufficiency is associated with reduced neuronal division and disruption of periglomerular interneurons in mice. Frontiers Cell Dev. Biol. 8:113. PMID 32161758. PMCID PMC7054221.

 

Furusho M, Ishii A, Hébert JM, Bansal R. (2019). Developmental stage-specific role of Frs adapters as mediators of FGF-Receptor signaling in the oligodendrocyte-lineage cells. Glia 68:617-630. PMID 31670856. PMCID pending.

Kamatkar N, Levy M, Hébert JM. (2019). Development of a monomeric inhibitory RNA aptamer specific for FGFR3 that acts as an activator when dimerized. Mol. Ther. Nuc. Acids, in press.

Kang W. Nguyen KCQ, Hébert JM. (2019). Transient redirection of SVZ-stem cells to oligodendrogenesis by FGFR activation promotes remyelination. Stem Cell Reports 12:1223-1231.

Einstein blog: http://blogs.einstein.yu.edu/the-science-of-replacement-as-a-means-of-escaping-aging/

Hébert JM, Vijg J. (2018). Cell replacement to reverse brain aging: challenges, pitfalls, and opportunities. Trends in Neuroscience 41: 267-279.

Antoine MW, Zhu X, Dieterich M, Brandt T, Vijayakumar S, McKeehan N, Arezzo J, Zukin RS, Borkholder D, Jones SM, Frisina R, Hébert JM. (2018). Left-right brain lateralization in mammals due to early uneven ear input. PLoS Biology 16: e2002988.

Nandi S, Alvina K, Lituma PJ, Castillo PE, Hébert JM. (2018). Neurotrophin and FGF signaling adapter proteins, FRS2 and FRS3 regualte dentate granule cell maturation and exitatory synaptogenesis. Neuroscience 369: 192:201.

Nandi S, Gutin G, Blackwood CA, Kamatkar NG, Lee KW, Fishell G, Wang F, Goldfarb M, Hébert JM. (2017). Context-driven, receptor-dependent usage of an intracellular adapter governs specificity in FGF signal transduction. J. Neurosci. 37:5690-5698.

Antoine MW, Vijayakumar S, McKeehan N, Jones S, Hébert, JM. (2017). The severity of vestibular dysfunction in deafness as a determinant of comorbid hyperactivity or anxiety. J. Neurosci. 37: 5144-5154.

Andriani GA, Faggioli F, Baker D, Dollé MET, Sellers RS, Hébert JM, van Steeg H, Hoeijmakers J, Vijg J, Montagna C. (2016). Whole chromosome aneuploidy in the brain of BubR1H/H and Ercc1 -/Δ7 mice. Hum. Mol. Gen. 25: 755-765.

Nandi S, Chandramohan D, Fioriti L, Melnick AM, Hébert JM, Mason CE, Kandel ER, Rajasethupathy P. (2016). A role for piRNAs in retrotransposon silencing in the mammalian brain. P.N.A.S. U.S.A. 113: 12696-12702.

Kang W, Hébert JM. (2015). FGF signaling is necessary for neurogenesis in young mice and sufficient to reverse its decline in old mice. J. Neuroscience 35: 10217-10223.

Kang W, Balordi F, Su N, Chen L, Fishell G, Hébert JM. (2014). Astrocyte activation in both normal and injured brain is suppressed by FGF signaling. PNAS USA, 111: E2987-E2995.

Antoine M, Hübner CA, Arezzo JC, Hébert JM. (2013). A causative link between inner ear defects and long-term striatal dysfunction. Science 341: 1120-1123.

Diaz F, McKeehan N, Kang W, Hébert JM. (2013). Apoptosis of glutamatergic neurons fails to trigger a neurogenic response in the adult neocortex. J. Neuroscience 33: 6278-6284.

Hébert JM. (2013). Only scratching the cell surface; extracellular signals in cerebrum development. Curr. Opin. Genet. Dev. 23: 470-474.

Tole S, Hébert JM. (2013). Telencephalic patterning. In “Patterning and cell type specification in the developing CNS and PNS, Comprehensive Developmental Neuroscience”, Volume 1, Elsevier, ed. Pasko Rakic and John Rubenstein. p. 3-24.

Paek H, Antoine M, Diaz F, Hébert JM. (2012). Increased b-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. Dev. Dyn. 241: 242-246.

Fernandes M, Antoine M, Hébert JM. (2012). SMAD4 is essential in generating rhombic lip-derived neurons during cerebellar development. Dev. Biol. 365: 82-90.

Kang W, Hébert JM. (2012). A Sox2 BAC transgenic approach for targeting adult neural stem cells. PLoS ONE 7: e49038.

Khonsari RH, Delezoide AL, Kang W, Hébert JM, Bessières B, Bodiguel V, Collet C, Legeai-Mallet L, Sharpe PT, Fallet-Bianco C. (2012). Central nervous system malformations and deformations in FGFR2-related craniosynostosis. Am. J. Med. Genet. PartA 158: 2797-2806. PMID 22987770.

Paek H, Hwang JY, Zukin RS, Hébert JM. (2011). b-catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4. Dev. Cell 20: 689-699.

Hébert JM. (2011). FGFs: neurodevelopment's Jack-of-all-trades - how do they do it? Frontiers in Neurogenesis 5: 133.

Kang W, Hébert JM. (2011). Signaling pathways in reactive astrocytes, a genetic perspective. Mol. Neurobiol. 43: 147-154.

Furusho M, Kaga Y, Ishii A, Hébert JM, Bansal R. (2011). FGF signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain. J. Neurosci. 31: 5055-5066.

Ferretti E, Li B, Zewdu R, Wells V, Hébert JM, Karner C, Anderson MJ, Williams T, Dixon J, Dixon MJ, Depew MJ, Selleri L. (2011). A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis. Dev. Cell 21: 627-641.

Maier E, von Hofsten J, Nord H, Fernandes M, Paek H, Hébert JM, Gunhaga L. (2010). Opposing activities of FGF and BMP regulate the olfactory sensory versus respiratory epithelial cell fate decision. Development 137: 1601-1611.

Paek H, Gutin G, Hébert JM. (2009). FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development 136: 2457-2465.

Kang W, Wong LC, Shi S, Hébert JM. (2009). The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis. J. Neurosci. 29: 14571-14580.

Hébert JM, Fishell G. (2008). The genetics of telencephalon patterning, some assembly required. Nat. Rev. Neurosci., 9: 678-685.

Chang W, Lin Z, Kulessa H, Hébert J, Hogan BLM, Wu DK. (2008). Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genetics 4: e1000050. PMID: 18404215, PMCID: PMC2274953.

Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hébert JM, Jones K, Kessaris N, de Rouvroit CL, Richardson WD, O’Leary D, Goffinet AM, Tissir F. (2008). Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science 320: 946-949. PMID: 18487195, PMCID: PMC2746700.

Fernandes M, Hébert JM. (2008). The ups and downs of holoprosencephaly, dorsal versus ventral patterning forces. Clin. Gen. 73: 413-423.

Fernandes M, Gutin G, Alcorn H, McConnell SK, Hébert JM. (2007). Mutations in the BMP pathway in mice supports the existence of two molecular classes of holoprosencephaly. Development 134: 3789-3794. PMID: 17913790.

Hanashima C, Fernandes M, Hébert JM, Fishell G. (2007). The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J. Neurosc. 27: 11103-11111. PMID: 17928452.

Gutin G*, Fernandes M*, Pallazolo L, Paek H, Kai Y, Ornitz D, McConnell SK, Hébert JM. (2006). FGF acts independently of SHH to generate ventral telencephalic cells. Development 133: 2937-2946. PMID: 16818446. *co-first authors

Arnold JS, Werling U, Braunstein EM, Liao J, Nowotschin S, Edelmann W, Hébert JM, Morrow BE. (2006). Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 133: 977-987.

Tole S*, Gutin G*, Remedios R, Bhatnagar L, Hébert JM. (2006). Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Dev. Biol. 289: 141-151. PMID: 16309667. *co-first authors

Hébert JM. (2005). Unraveling the molecular pathways that regulate early telencephalon development. Curr. Top. in Dev. Biol. 69: 17-37.

Related News

  • Marmur Awards Celebrates 25 Years
    Feature
    Marmur Awards Celebrates 25 Years

    Apr 07, 2021

  • News Release
    Inner-Ear Disorders May Cause Hyperactivity

    Sep 05, 2013

In the News

  • Monday, September 9, 2013

    The New York Times' Science Times section interviews Jean Hébert, Ph.D., about his research featured in Science that found a link between hyperactivity and an inner ear defect in mice. Because the study was preliminary, Dr. Hébert cautions that parents should not start testing their hyperactive children for hearing loss. Dr. Hébert is professor in the Dominick P. Purpura Department of Neuroscience and of genetics.

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Bronx, NY 10461
718.430.2000
Affiliated With
Montefiore Health
Yeshiva University
  • About Einstein
    • History
    • Dean's Page
    Administration
    • Administrative Departments
    Alumni
    Careers
  • Centers (Research)
    Contact Us
    Departments
    Diversity
    • Report a Bias Incident
    Donors
    • Giving to Einstein
  • Education
    • Graduate Medical Education (G.M.E.)
    • Graduate Program (Ph.D.)
    • Master of Science in Bioethics (M.B.E.)
    • Master of Science in Clinical Research Methods (M.S.)
    • Medical Program (M.D.)
    • MSTP Program (M.D. - Ph.D.)
  • Einstein Senate
    Faculty Directory
    Health
    • Affiliated Institutions
    • Clinical Programs
    • Global Health
    • E-M Partnership
    INTRANET
    Library
    Luminis Portal
  • Newsroom
    • Blog
    • Einstein in the News
    • Expert List for Media
    • Features
    • Magazine
    • Multimedia
    • News Releases
    • Research Briefs
    • Social Media Hub
  • Policies
    Research
    • Collaboration Zone
    • Scientific Resources
    Video
    Visitors
    • Campus Map
    • Directions
    Webmail
ALBERT EINSTEIN ®
College of Medicine
© Albert Einstein College of Medicine | Privacy Policy | Terms of Use | Webmaster