David Entenberg’s research interests are in the development of enabling technologies for biological research. With a background in laser based experimental quantum physics he brings skills in optical, mechanical, electrical, software and instrument design to biological research. Previous work has included the design and development of several robotics-based high-throughput automated biological assays utilizing real time PCR and MALDI-TOF protocols, novel microscopes including a fast switching, multi-channel TIRF microscope, a video rate multiphoton microscope, and a two-laser, OPO based multiphoton microscope. Current projects are focused on utilizing surgical engineering to develop and validate techniques for expanding the utility of mouse models within intravital imaging. This work has included mammary, abdominal, brain, lymphatic and lung imaging windows for studying cancer metastasis to secondary sites in vivo, as well surgically implantable photolithographic microdevices designed to directly alter the local (<300um) microenvironment in vivo and during intravital imaging.
He has authored several book chapters on multiphoton microscopy and intravital imaging and is co-Director of Einstein’s Quantitative Imaging of Cells course. He currently serves as co-Director of Einstein's Gruss Lipper Biophotonics Center, Director of Technological Development within the Integrated Imaging Program, and Leader of the Computational Analysis of Biomarkers Program within the Integrated Imaging Program for Cancer Research.