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  • Yongwei Zhang, Ph.D.

Yongwei Zhang, Ph.D.

Yongwei Zhang

Principal Associate, Department of Cell Biology

Area of Research: CRISPR; Mouse model; DNA cloning; DNA mismatch repair

Contact Information

718.678.1087718.430.8574yongwei.zhang@einsteinmed.edu

Albert Einstein College of Medicine
Michael F. Price Center
1301 Morris Park Avenue, Room 275
Bronx, NY 10461

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Professional Interests

I have worked on the research of DNA mismatch repair system, type 2 diabetes, DNA cloning methods and mouse models. Currently I am mainly engaged in the generation of genetically modified mouse models and cell lines using CRISPR technology.

Selected Publications

  1. Chen CC, Avdievich E, Zhang Y, Zhang Y, Wei K, Lee K, Edelmann W, Jasin M, LaRocque JR. EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells. DNA Repair (Amst). 2017 Sep;57:98-106.
  2. Zhang Y, Werling U, Edelmann W. Seamless Ligation Cloning Extract (SLiCE) cloning method. Methods Mol Biol. 2014;1116:235-44
  3. Zhang Y, Werling U, Edelmann W. SLiCE: a novel bacterial cell extract-based DNA cloning method. Nucleic Acids Res. 2012 Apr;40(8):e55. Epub 2012 Jan 12.
  4. Patent: Winfried Edelmann, Yongwei Zhang. Cell Extract Promoted Cloning. U.S. Utility Patent No. US8609374B2. (2013).
  5. Avdievich E, Reiss C, Scherer SJ, Zhang Y, Maier SM, Jin B, Hou H Jr, Rosenwald A, Riedmiller H, Kucherlapati R, Cohen PE, Edelmann W, Kneitz B. Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proc Natl Acad Sci U S A. 2008; 105:4247-52.6 DuBois JC, Ray AK, Gruber RC, Zhang Y, Aflakpui R, Macian-Juan F, Shafit-Zagardo B. Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. Front Immunol. 2019 Jul 25;10:1738. 7 Milano CR, Holloway JK, Zhang Y, Jin B, Smith C, Bergman A, Edelmann W, Cohen PE. Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis. G3 (Bethesda). 2019 Jun 5;9(6):1839-18508 Zhao X, Zhang Y, Wilkins K, Edelmann W, Usdin K. MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective. PLoS Genet. 2018 Oct 12;14(10):e1007719.
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