Journal articles
Naranjo S^, Cabana CM^, LaFave LM, Westcott MK, Romero R, Ghosh A, Liao LX, Schenkel JM, Del Priore I, Bhutkar A, Yang D, Jacks T. Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform. Accepted. Genes and Development.
Zhao T^, Chiang ZD^, Morriss JW, LaFave LM, Murray EM, Del Priore, Meli K, Lareau CA, Nadaf NM, Li J, Earl AS, Macosko EZ, Jacks T, Buenrostro JD*, Chen F*. Spatial genomics enables multi-modal study of clonal heterogeneity in tissues. Nature. 2022 Jan;601(7891):85-91. doi: 10.1038/s41586-021-04217-4. PMID: 34912115.
Concepcion C, Ma S#, LaFave LM#, Bhutkar A#, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sanchez-Rivera FJ, Meli K, Gupta M, Bronson RT, Riely GJ, Rekhtman N, Rudin CM, Kim CF, Regev A, Buenrostro JD, Jacks T. Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung. Cancer Discovery. 2021 Sep 24:candisc.0248.2021. doi: 10.1158/2159-8290.CD-21-0248. Epub ahead of print. PMID: 34561242.
Del Priore I^, Ma S^, Strecker J, Jacks T, LaFave LM*, Buenrostro JD*. Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma. STAR Protocols. 2021 Jun 3;2(2):100583. doi: 10.1016/j.xpro.2021.100583. PMID: 34142101; PMCID: PMC8185305.
Ma S, Bing Z, LaFave LM, Chiang Z, Hu Y, Ding J, Brack A, Kartha VK, Law T, Lareau C, Hsu Y, Regev* A, Buenrostro JD*. Chromatin-mediated lineage priming and chromatin potential identified by shared single cell profiling of RNA and chromatin. Cell. 2020 Oct 20:S0092-8674(20)31253-8. PMID: 33098772.
LaFave LM, Kartha VK#, Ma S#, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott P, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD*, Jacks T*. Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma. Cancer Cell. 2020 Aug 10;38(2):212-228.e13. PMID: 32707078.
Highlight: Drapkin, BJ and Minna JD. Studying Lineage Plasticity One Cell at a Time. Cancer Cell. 2020 Aug (2); 150-152.
LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller M, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov A, Chung YR, Khodos I, DeStanchina A, Ouerfelli O, Adusumilli P, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong S, Levine RL. Reply to “Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status.” Nature Medicine 2016 Jun 578-9; PMID: 27270773.
Meyer SC, Keller MD, Woods BA, LaFave LM, Bastian L, Kleppe M, Bhagwat N, Marubayashki S, Levine RL. Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis. Blood. 2014 Oct 2;124(14):2280-4; PMID 25115888.
Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung YR, Kuscu C, Hricik T, Ndiaye-Lobry D, LaFave LM, Koche R, Shih AH, Guryanova OA, Kim E, Li S, Pandey S, Shin JY, Telis L, Liu J, Bhatt PK, Monette S, Zhao X, Mason CE, Park CY, Bernstein BE, Aifantis I, Levine RL. Deletion of ASXL1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med. 2013 Nov; 210(12):2641-59; PMID 24218140
Abdel-Wahab O^, Adli M^, LaFave LM^, Gao, J, Hricik T, Shih AH, Pandey S, Patel J, Perna F, Zhao X, Taylor JE, Park CY, Carrol M, Melnick A, Nimer SD, Jaffe JD, Aifantis I, Bernstein BE, Levine RL. ASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-Mediated Gene Repression. Cancer Cell. 2012 Aug; 22(2); 180-93; PMID 22897849
Dey, A, Seshasayee, D, Noubade R, French D, Liu J, Kirkpatrick D, Pham V, Lill J, Bakalarski C, Wu J, Katavolos P, LaFave LM, Modrusan Z, Seshagiri S, Dong K, Lin Z, Balazs M, Suriben R, Newton K, Hymowitz S, Garcia-Manero G, Martin F, Levine RL, Dixit V. Loss of tumor suppressor BAP1 promotes myeloid transformation. Science. 2012 Sep; 337(6101); 1541-6; PMID 22878500
Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders L, Mullaly A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gonen M, Estrov Z, Ebert, BL, Chiosis G, Nimer SD, Bernstein BE, Verstovsek S, Levine RL. Heterodimeric JAK-STAT Activation as a Mechanism of Persistence to JAK2 Inhibitor Therapy. Nature. 2012 Sep; 489(7414); 155-9. PMID: 22820254
Dawson MS, Bannister AJ, Saunders L, Wahab OA, Liu F, Nimer SD, Levine RL, Gottgens B, Kouzarides T, Green AR. Nuclear JAK2. Blood. 2011 Dec; 118(26):6987-8; PMID 22194397.
Abuzeid WM, Davis S, Tang AL, Saunders L, Brenner JC, Lin J, Fuchs JR, Light E, Bradford CR, Prince ME, Carey TE. Sensitization of head and neck cancer to Cisplatin through the use of a novel curcumin analog. Arch Otolaryngol Head Neck Surg. 2011 May; 137(5):499-507; PMID: 21576562
Brenner JC, Graham MP, Kumar B, Saunders LM, Kupfer R, Lyons RH, Bradford CR, Carey TE. Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 Apr; 32(4):417-26; PMID 19760794.
Reviews and commentaries
Bayin NS*, McKinley KL, LaFave LM*. Research vision workshopping: Peer mentoring to support the transition to independence. Cell. 2023 Mar 30;186(7):1295-1299. doi: 10.1016/j.cell.2023.03.002. PMID: 37001493.
LaFave LM*, Savage RE, Buenrostro JD*. Single-cell Epigenomics Reveals Mechanisms of Cancer Progression. Annual Review of Cancer Biology. Ahead of Print. Vol 6.
LaFave LM*, Buenrostro JD*. Unlocking PDAC initiation with AP-1. Nature Cancer 2, 14–15 (2021).
LaFave LM, Levine RL. Targeting a regulator of protein homeostasis in myeloproliferative neoplasms. Nature Medicine. 2016 Jan (1); 20-1; PMID: 26735404.
LaFave LM, Levine RL. Mining the epigenetic landscape in ALL. Nat Genet. 2013 Nov;45(11):1269-70; PMID 24165727
LaFave LM, Levine RL. JAK2 the future: therapeutic strategies for JAK-dependent malignancies. Trends in Pharmacol Sci. 2012 Nov; 33(11); 574-82. PMID: 22995223