Structural Biology Shared Resource (SBSR) The Structural Biology Shared Resource (SBSR) supports a wide range of protein science technologies for identifying new targets and defining molecular mechanisms, and for the generation of new tool compounds and therapeutic leads. These services include (1) state-of-the-art protein production; (2) high resolution structure determination by X-ray crystallography, NMR and cryo-EM; (3) significantly enhanced mass spectrometry-based proteomics analyses; and (4) the flexibility to implement additional advanced technologies to support the needs of MECC members. Through the SBSR, MECC members and other SRs have access to state-of-the-art infrastructure located in-house and at regional centers (New York Structural Biology Center) and national laboratories (Brookhaven National Labs). The utility of these resources is maximized by sustained access to dedicated local expertise. SBSR services can be reached at: Macromolecular Therapeutics Development Facility Services Structural NMR services Proteomic Services X-ray Crystallography Services