Mouse Cardiac Surgery and Physiology Core

The Mouse Cardiac Surgery and Physiology Core supports Einstein investigators in delineating the impact of genes, drugs and metabolites on cardiac function. The core employs multiple approaches to analyze cardiovascular structure and function in wild-type and genetically manipulated mice. The technically experienced staff of the core performs the analyses and provides the data to the investigator. When possible, training is also offered. Contact core staff to determine the availability of new surgical and measurement services being developed.

Services

Access the Services

  • Procedures/measurements currently offered:
  • Reperfused myocardial infarction experiments (open-chest and closed-chest models of murine coronary ischemia/reperfusion)
  • Non-reperfused myocardial infarction experiments (permanent coronary occlusion)
  • Experimental models of cardiac hypertrophy and fibrosis in the mouse (model of transverse aortic constriction, model of cardiac fibrosis due to brief repetitive coronary occlusion/reperfusion)
  • Assessment of cardiac systolic and diastolic function using 2D-echocardiography and invasive hemodynamic monitoring
  • Assessment of cardiac remodeling to study the geometric alterations of the ventricle following cardiac injury using echocardiography (M-mode and two-dimensional) and quantitative morphometry
  • Insertion of arterial (e.g. carotid) and venous (e.g. jugular) catheters for blood pressure measurements,drug infusion,or cell therapy.Tail vein injections.
  • Implantation of osmotic minipumps for drug infusion (e.g. Alzet)
  • *Contact Core staff to determine the availability of new surgical and measurement services being developed .
Related Shared Facilities
Related Shared Facilities
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Center Affiliations
Center Affiliations
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Selected Publications

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Location and Contacts

Mouse Cardiac Surgery and Physiology Core Forchheimer G45

  • Nikolaos G. Frangogiannis, M.D.
    Scientific Director
    718-430-3546

  • Ya Su, M.D.
    Operations Director
    718-430-2774