Proteomics (LMAP)

The Proteomics Facility, supported by the Laboratory for Macromolecular Analysis and Proteomics (LMAP), provides Einstein researchers with a comprehensive mass spectrometry resource for analysis of proteins, peptides and other selected families of biomolecules. Expert staff scientists are available to help plan and execute a successful proteomics based analysis. They also assist in data analysis, including statistics and data visualization.

Services

Access the Services

  • The Laboratory for Macromolecular Analysis and Proteomics (LMAP)/Protemics Core:
  • Identification of proteins from gel bands, immunoaffinity isolations, protein complexes or specialty preparations
  • Identification and localization of posttranslational modifications
  • Top down analysis of small proteins or large fragments for localization of posttranslational modifications
  • Spatial localization of molecules by mass spectrometry
  • Quantitative proteomics by SILAC, SILAM, 18O, iTRAQ, and label free methods
  • Hydrogen/deuterium exchange-mass spectrometry for studies of protein dynamics and biomolecular interactions
  • Confirmation of synthetic and recombinant molecules
  • High resolution analysis by FT-ICR-MS of metabolites, drugs, peptides and small molecules
  • Multiple reaction monitoring assays and pharmacokinetics
  • Kinetic isotope effect (KIE) determinations for drug design
  • Identification of carbohydrates and lipids
  • Identification of unknowns
  • Off-line separation of components followed by mass spectrometry identification
  • Assistance or consultation on sample preparation and experimental design
  • Advanced data analysis
Related Shared Facilities
Related Shared Facilities

Analytical Imaging

Macromolecular Therapeutics Development

Structural NMR

Center Affiliations
Center Affiliations

Montefiore Einstein Cancer Center

Selected Publications

ACS Chemical Biology. 2012 Apr 20;7(4):744-52 Journal of American Chemical Society. 2012 Jan 25;134(3):1468-70 Proteomics, Clinical Applications. 2012 Oct;6(9-10):502-6 The Journal of Biological Chemistry. 2012 Feb 24;287(9):6503-17

Location and Contacts

Proteomics (LMAP) Ullmann 403

  • Simone Sidoli, Ph.D.
    Scientific Director
    718-430-3475

  • Louis M. Weiss, M.D., M.P.H.
    Associate Scientific Director
    718-430-2142

  • Edward Nieves
    Operations Director
    718-430-3476