Proteomics (LMAP)

The Proteomics Facility, supported by the Laboratory for Macromolecular Analysis and Proteomics (LMAP), provides Einstein researchers with a comprehensive mass spectrometry resource for analysis of proteins, peptides and other selected families of biomolecules. Expert staff scientists are available to help plan and execute a successful proteomics based analysis. They also assist in data analysis, including statistics and data visualization.

  • The Laboratory for Macromolecular Analysis and Proteomics (LMAP)/Protemics Core:
  • Identification of proteins from gel bands, immunoaffinity isolations, protein complexes or specialty preparations
  • Identification and localization of posttranslational modifications
  • Top down analysis of small proteins or large fragments for localization of posttranslational modifications
  • Spatial localization of molecules by mass spectrometry
  • Quantitative proteomics by SILAC, SILAM, 18O, iTRAQ, and label free methods
  • Hydrogen/deuterium exchange-mass spectrometry for studies of protein dynamics and biomolecular interactions
  • Confirmation of synthetic and recombinant molecules
  • High resolution analysis by FT-ICR-MS of metabolites, drugs, peptides and small molecules
  • Multiple reaction monitoring assays and pharmacokinetics
  • Kinetic isotope effect (KIE) determinations for drug design
  • Identification of carbohydrates and lipids
  • Identification of unknowns
  • Off-line separation of components followed by mass spectrometry identification
  • Assistance or consultation on sample preparation and experimental design
  • Advanced data analysis

Location and Contacts

Proteomics (LMAP) Ullmann 403
  • Simone Sidoli, Ph.D.
    Scientific Director

  • Louis M. Weiss, M.D., M.P.H.
    Associate Scientific Director

  • Edward Nieves
    Operations Director