Understanding Virus–Host Interactions

Understanding Virus–Host Interactions

Some genes code for transfer RNA (tRNA) molecules, which are crucially important in synthesizing proteins based on instructions in the genetic code. Viruses are thought to be under selective pressure to maintain compact genomes, causing them to depend on the host cell’s translational machinery to reproduce themselves. However, some viruses encode abundant transfer RNA (tRNA) genes—presumably for a reason.

In a study published online on June 17 in Cell Systems, Libusha Kelly, Ph.D., and colleagues examined whether carrying a large number of tRNA genes—18 in total—confers a survival advantage to a virus that infects marine Vibrio bacteria. The researchers found that viral infection causes bacterial DNA and RNA (including tRNA) to degrade and that tRNA levels reach a minimum 15 minutes into infection, while newly synthesized viral particles aren’t released until 30 minutes into infection. In addition, all 18 of the virus’ tRNA genes are expressed during infection. The findings suggest that viruses possess so many tRNA genes because they must carry out translation and protein synthesis even as their hosts’ DNA and RNA are degraded during infection.

Dr. Kelly is an associate professor of systems & computational biology and of microbiology & immunology at Einstein.

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