The Entenberg Lab focuses on developing novel photonics based assays for biological research, using them to investigate the mechanisms of cancer metastasis, and translating basic science findings into clinical applications through the development and validation of advanced image analysis and digital pathology based biomarkers.
Recent work has focused on development and validation of biomarkers of metastasis, and on expanding the utility of mouse models for intravital imaging by utilizing surgical engineering to develop and optimize protocols novel surgical protocols and implantable imaging windows. This work has included mammary, abdominal, brain, lymphatic, and lung imaging windows for studying cancer metastasis to secondary sites in vivo, as well surgically implantable photolithographic micro-devices designed to directly alter the local (<300 µm) microenvironment in vivo and during intravital imaging.