Harijan, R.K., Zoi, I., Antoniou, D., Schwartz, S.D., Schramm, V.L. “Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels”. Proc Natl Acad Sci U S A. 115, E6209-E6216 (2018). PMC29915028
Schramm, V.L., Schwartz, S.D. “Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence.” Biochemistry 57, 3299-3308 (2018). PMC6008225
Ducati, R.G., Namanja-Magliano, H.A., Harijan, R.K., Fajardo, J.E., Fiser, A., Daily, J.P., Schramm, V.L. “Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum”. Proc Natl Acad Sci U S A. 115, 2114-2119 (2018). PMC5834662
Harris, L.D., Harijan, R.K., Ducati, R.G., Evans, G.B., Hirsch, B.M., Schramm, V.L. “Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.” ACS Chem Biol. 13, 152-160 (2018). PMID29178779
Evans, G.B., Tyler, P.C., Schramm, V.L. “Immucillins in Infectious Diseases.” ACS Infect Dis. 4, 107-117 (2018). PMC6034505
Ducati RG, Firestone RS, Schramm VL. “Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum.” Biochemistry 56, 6368-6376 (2017). PMC5926801
Stratton, C.F., Poulin, M.B., Schramm, V.L. “Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions.” Methods Enzymol 596, 1-21 (2017). PMID28911767
Firestone, R.S., Schramm, V.L. “The Transition-State Structure for Human MAT2A from Isotope Effects.” J. Am. Chem. Soc. 139, 13754-13760 (2017). PMC5674783
Moggré, G.J., Poulin, M.B., Tyler, P.C., Schramm, V.L., Parker, E.J. “Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.” ACS Chem Biol. 12, 2662-2670 (2017). PMID28872824
Namanja-Magliano HA, Evans GB, Harijan RK, Tyler PC, Schramm VL. “Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.” Biochemistry 56, 5090-5098 (2017). PMC6019266
Gebre, S.T., Cameron, S.A., Li, L., Babu, Y.S., Schramm, V.L. “Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase. J. Biol. Chem. 292, 15907-15915 (2017). PMC5612120
Harijan, R.K., Zoi, I., Antoniou, D., Schwartz, S.D. and Schramm, V.L. “Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase.” Proc. Natl. Acad. Sci. 114, 6456-6461 (2017). PMC5488955
Firestone, R.S., Cameron, S.A., Karp, J.M., Arcus, V.L. and Schramm, V.L. “Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5’-Methylthioadenosine.” ACS Chem Biol 12, 464-473 (2017). PMC5462123
Stratton, C.F., Poulin, M.B., Du, Q. and Schramm, V.L. “Kinetic Isotope Effects and Transition state Strucutre for Human Phenylethanolamine N-Methyltransferase.” ACS Chem Biol 12, 342-346 (2017) PMC5553282