John GR, Shankar SL, Shafit-Zagardo B, Massimi A, Lee SC, Raine CS, Brosnan C. 2002. Multiple Sclerosis: Re-expression of a developmental pathway that restricts remyelination. Nature Med 8:1115-1121.
Shankar SL, O’Guin K, McMorris FA, Varnum B, Basch RS, Shafit-Zagardo B. 2003. The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. J Neurosci 23(10):4208-4218.
Shankar SL, O’Guin K, Kim, M, Varnum B, Lemke G, Brosnan CF, Shafit-Zagardo B. 2006. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci 26:5638-5648.
Weinger JG, Gohari P, Yan Y, Backer JM, Varnum B, Shafit-Zagardo B. 2008. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. J Neurochem. 106:134-146.
Weinger JG, Omari KM, Marsden K, Raine CS, Shafit-Zagardo B. 2009. Upregulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. Am. J. Pathol. 175:283-293.
Tsiperson V, Li X, Schwartz G, Raine CS, Shafit-Zagardo B. 2010. Gas6 enhances clearance of myelin debris, remyelination and axonal survival after cuprizone toxicity. PlosOne. Dec 23;5(12):e15748.
Weinger JG, Brosnan CF, Loudig O, Goldberg MF, Macian F, Arnett H, Prieto AL, Tsiperson V, Shafit-Zagardo B. 2011. Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis. J Neuroinflammation. 8:49-56.
Weinger JG, Davies P, Acker CM, Brosnan CF, Tsiperson V, Bayewitz A, Shafit-Zagardo B. 2012. Mice devoid of Tau have increased susceptibility to neuronal damage in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Neuropathol Exp Neurol. 71:422-433.
Tsiperson V, Gruber R, Goldberg M, Jordan A, Weinger JG, Macian F, Shafit-Zagardo B. 2013. Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein–Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling. J. Immunol. 190:1528-1539.
O’Guin KN, Raine CR, Gruber RC, Poulus BK, Shafit-ZagardoB. 2014. Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures, ASN Neuro. ASN NEURO 6(1):art:e00135.doi:10.1042/AN20130022.
Gruber RC, Ray A, Guzik HM, Burek D, García de Frutos P, Kaspar B, Shafit-Zagardo B. 2014. Targeted growth-arrest specific protein 6 (Gas6) delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis (EAE). J. Neurosci. 34:16320-16335.
Ray A, DuBois JC, Gruber RC, Guzik HM, Gulinello ME, Perumal G, Raine C, Kozakiewicz L, Williamson J, Shafit-Zagardo B. Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation and less remyelination following cuprizone exposure. Glia, 65(12):2051-2069, 2017. PMID: 28925029
Shafit-Zagardo B, Gruber RC, DuBois JC. The role of TAM family receptors and ligands in the nervous system: From development to pathobiology. Pharmacol Ther. 188:97-117, 2018. doi: 10.1016/j.pharmthera.2018.03.002.
Mocholi E, Dowling SD, Botbol Y, Gruber RC, Ray AK, Vastert S, Shafit-Zagardo B, Coffer PJ, Macian F. Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy.
Cell Rep. 24(5):1136-1150, 2018. PMID: 30067971
DuBois JC, Ray AK, Gruber RC, Zhang Y, Aflakpui R, Macian-Juan F, Shafit-Zagardo B. Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. Front Immunol. 10:1738, 2019. PMID: 31404142
DuBois JC, Ray AK, Davies P, Shafit-Zagardo B. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis. J Neuroinflammation. 17(1):324, 2020. PMID: 33121494