Roche, C.J., Guo, F. and Friedman, J.M. (2006) Molecular level probing of preferential hydration and its modulation by osmolytes through the use of pyranine (HPT) complexed to hemoglobin. J Biol Chem 281 38757-68. Nacharaju, P., J. M. Friedman, et al. (2007).
"Combining the influence of two low O2 affinity-inducing chemical modifications of the central cavity of hemoglobin." Biochemistry46(15): 4554-64.Samuni, U., D. Dantsker, et al.(2007).
"Ligand recombination and a hierarchy of solvent slaved dynamics: The origin of kinetic phases in hemeproteins." Gene 398(1-2): 234-48. Samuni, U.; Roche, C. J.; Danstker, D.; Friedman, J. M., Conformational dependence of hemoglobin reactivity under high viscosity conditions: the role of solvent slaved dynamics 2007, JACS 129(42):12756-64. Cabrales, P.; Friedman, J. M., Mechanisms for Why PEGylated Hemoglobins Can Function as Perfusion Enhancing Blood Substitutes. Transfusion Alternatives in Tranfusion Medicine 2007, 9, 281-293. Samuni U, Roche CJ, Dantsker D, Friedman JM. 2008.
T and R State Tertiary Relaxations in Sol-Gel Encapsulated Hemoglobin In: M. Bolognesi G. di Prisco, C. Verde, editor. Dioxygen Binding and Sensing: Springer. p 134-150.D. Giordano, L. Boechi, A. Vergara, M.A. Marti, U. Samuni, D. Dantsker, L. Grassi, D.A. Estrin, J.M. Friedman, L. Mazzarella, G. di Prisco, and C. Verde, The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species--oxygen-binding equilibria, kinetics and molecular dynamics. Febs J 276 (2009) 2266-77. Friedman, A. J., G. Han, et al.(2008).
"Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites." Nitric Oxide 19(1): 12-20.Samuni U, Friedman JM. 2005.
Proteins in motion: resonance Raman spectroscopy as a probe of functional intermediates. Methods Mol Biol 305:287-300.Das, T.K., Dewilde, S., Friedman, J.M., Moens, L. and Rousseau, D.L. (2006) Multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins.
J Biol Chem 281, 11471-9.Samuni U, Roche CJ, Dantsker D, Juszczak LJ, Friedman JM. (2006) Modulation of Reactivity and Conformation within the T-Quaternary State of Human Hemoglobin: The Combined Use of Mutagenesis and Sol-Gel Encapsulation. Biochemistry 45(9):2820-35. Navati, M. S. and Friedman, J. M., (2006).
Sugar-derived glasses support thermal and photo initiated long range electron transfer processes over macroscopic distances. J Biol Chem 281 36021-8.Roche, C.J., Dantsker, D., Samuni, U. and Friedman, J.M. (2006) Nitrite Reductase Activity of Sol-gel Encapsulated Deoxy Hemoglobin: Influence of Quaternary and Tertiary Structure. .J. Biol. Chem. 281 36874-82. Roche, C.J., Guo, F. and Friedman, J.M. (2006) Molecular level probing of preferential hydration and its modulation by osmolytes through the use of pyranine (HPT) complexed to hemoglobin. J Biol Chem 281 38757-68.Nacharaju, P., J. M. Friedman, et al. (2007).
"Combining the influence of two low O2 affinity-inducing chemical modifications of the central cavity of hemoglobin." Biochemistry46(15): 4554-64.Samuni, U., D. Dantsker, et al.(2007).
"Ligand recombination and a hierarchy of solvent slaved dynamics: The origin of kinetic phases in hemeproteins." Gene 398(1-2): 234-48. Samuni, U.; Roche, C. J.; Danstker, D.; Friedman, J. M., Conformational dependence of hemoglobin reactivity under high viscosity conditions: the role of solvent slaved dynamics 2007, JACS 129(42):12756-64.Ouellet, Y. H., R. Daigle, et al. (2008).
"Ligand binding to truncated hemoglobin N from mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water." J Biol Chem. 283(40): p. 27270-8. M.S. Navati, and J.M. Friedman, (2009)Reactivity of glass-embedded met hemoglobin derivatives towards external NO: implications for nitrite-mediated production of bioactive NO. JACS In press. Martinez, L. R., Han, G., Chacko, M., Mihu, M. R., Jacobson, M., Gialanella, P., Friedman, A. J., Nosanchuk, J. D. & Friedman, J. M. (2009) Antimicrobial and Healing Efficacy of Sustained Release Nitric Oxide Nanoparticles Against Staphylococcus Aureus Skin Infection.J Invest Dermatol.Han, G, Tar, M., Srini, D.K., Friedman, A, Melman, A., Friedman, J., and Davies, K.P. (2009) Nanoparticles as a novel delivery vehicle for therapeutics targeting erectile dysfunction J. Sexual Med. (In press).Friedman, A, and Friedman, J. (2009) New biomaterials for the sustained release of nitric oxide: past, present and future. Expert Opinion on Drug Delivery (In press). F. Guo, and J.M. Friedman, (2009)Charge Density-Dependent Modifications of Hydration Shell Waters by Hofmeister Ions. J Am Chem Soc.(In press)