Selected Publications
Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM. G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness (2012) Science Signaling 5:ra89
Vadas, O, Dbouk, HA, Shymanets, A, Perisic, O, Abi Saab, WF, Khalil, BD, Burke, JE, Harteneck, C, Bresnick, AR, Nurnberg, B, Backer, JM, and Williams, RL. Molecular determinants of PI3Kγ-mediated chemotaxis and transformation downstream of GPCRs. (2013) PNAS 2013 110:18862-7. PMID:24190998
Khalil, BD, Hsueh, C., Cao, Y, Abi Saab, WF, Wang, Y, Condeelis, JS, Bresnick, AR and Backer, JM. (2016) GPCR signaling mediates tumor metastasis via PI3Kβ. Cancer Research 76:2944-2953
Erami, Z, Khalil, BD, Salloum, G, Yao, Y, LoPiccolo, J., Shymanets, A, Nurnberg, B, Bresnick AR, and Backer, JM. Rac1-Stimulated Macropinocytosis Enhances Gβγ Activation of PI3Kβ. (2017) Biochemical Journal 474:3903-3914.
Dulyaninova, N, Chang, A, Khalil, B., Backer, JM, and Bresnick, AR. S100A4 regulates podosomes and MMP9 secretion by distinct myosin-IIA dependent and independent mechanisms. (2018) Mol. Biol. Cell 29(5):632-642
Heitz, SD, Hamelin, DJ, Hoffmann, RM, Greenbeerg, N, Salloum, G., Eramie, Z., Khalil, B., Shymanets,A, Steidle, EA, Gong, GQ, Nurrnberg, B, Burke, JE, Flanagan, JU, Bresnick, AR, and Backer, JM. A single discrete Rab5-binding site in phosphoinositide 3-kinaseβ is required for tumor cell invasion (2019) J. Biol. Chem 294:4621-4633.
Erami, Z., Heitz, SD. Bresnick AR, and Backer, JM. PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation (2019) Molecular Biology of the Cell 15:2367-2376.
Salloum, G., Jakubik, CT, Erami, Z., Heitz, SD, Bresnick, AR, and Backer, JM. PI3Kβ is selectively required for growth factor-stimulated micropinocytosis. (2019) J. Cell Sci. 132(16). pii: jcs231639