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  • Chaoyuan Kuang, M.D., Ph.D.

Chaoyuan Kuang, M.D., Ph.D.

Chaoyuan Kuang

Assistant Professor, Department of Oncology (Medical Oncology)

Assistant Professor, Department of Medicine (Oncology & Hematology)

Assistant Professor, Department of Molecular Pharmacology

Area of Research: Preclinical and translational research of colorectal and other GI cancers, apoptosis and regulated cell death, targeted and epigenetic therapies, mechanisms of action and resistance

Contact Information

718.430.2594718.430.8550chaoyuan.kuang@einsteinmed.edu

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Chanin Building, Room 628
Bronx, NY 10461

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Professional Interests

Our lab investigates the biology of colorectal cancer and other GI malignancies.  We study mechanisms of action and resistance in order to develop rational combinations and novel therapies.  One of our primary aims is to facilitate the conduct of early phase clinical trials with a focus on validation of key preclinical mechanisms.  We utilize a variety of techniques and models, including 2-D tissue culture, patient-derived organoids, xenografts, and high-throughput analysis of patient specimens.  We welcome trainees and potential collaborators to discuss ideas further.

Current topics of interest include:

- inhibition of anti-apoptosis proteins for the treatment of colorectal cancer

- bromodomain and extra-terminal domain (BET) inhibitors in the treatment of colorectal and other cancers

- immune priming of MSS colorectal cancer and other "immune-cold" tumors

Selected Publications

NEO2734, a novel dual bromodomain and histone acetyltransferase inhibitor, in the treatment of colorectal cancer [abstract].

Chaoyuan Kuang, Manbo Cai, Denise Risnik, Francis Giles, Lin Zhang. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1763.

 

Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside. Lizardo DY, Kuang C, Hao S, Yu J, Huang Y, Zhang L. Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188447. doi: 10.1016/j.bbcan.2020.188447. Epub 2020 Oct 6. PMID: 33035640

 
 
Biomarker analysis for UPCI 14-118: Phase II study of pembrolizumab in combination with azacitidine in patients with refractory metastatic colorectal cancer.
Chaoyuan Kuang, Yongseok Park, Nathan Bahary, Weijing Sun, James Ohr, John C. Rhee, Stanley M. Marks, H. Scott Beasley, Yongli Shuai, Yan Lin, Reetesh K. Pai, Anuradha Krishnamurthy, Hassane M. Zarour, James Herman, Edward Chu, and James J. Lee
Journal of Clinical Oncology 2020 38:4_suppl, 173-173
 
 
Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer.
Song X, Shen L, Tong J, Kuang C, Zeng S, Schoen RE, Yu J, Pei H, Zhang L. Theranostics. 2020 Jul 9;10(18):8098-8110. doi: 10.7150/thno.45363. eCollection 2020. PMID: 32724460
Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Bronx, NY 10461
718.430.2000
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