Ames, K., Kaur, I., Shi, Y., Tong, M., Sinclair, T., Hemmati, S., Glushakow-Smith, S.G., Tein, E., Gurska, L., Steidl, U., Dubin, R., Shan, J., Montagna, C., Pradhan, K., Verma, A., and Gritsman, K., Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells, Science Advances 2023. doi: 10.1126/sciadv.ade8222, PMID: 36812307
Folgado Marco, V., Ames, K., Chuen, J., Gritsman, K. & Baker, N., Haploinsufficiency of the essential gene RpS12 causes defects in erythropoiesis and hematopoietic stem cell maintenance, BioRxiv 2021, doi:https://doi.org/10.1101/2021.05.04.442585 (preprint), eLife 2023 (in press)
Gurska, L.M., Okabe, R., Schurer, A., Tong, M.M., Soto, M., Choi, D., Ames, K., Glushakow-Smith, S., Montoya, A., Tein, E., Miles, L.A., Cheng, H., Hankey-Giblin, P., Levine, R.L., Goel, S., Halmos, B., and Gritsman, K. Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms, Clinical Cancer Research 2022 Dec 20:CCR-22-1763. doi: 10.1158/1078-0432.CCR-22-1763. PMID: 36537918
Gurska LM, Ames K, Gritsman K., Signaling Pathways in Leukemic Stem Cells, Adv Exp Med Biol. 2019;1143:1-39. doi: 10.1007/978-981-13-7342-8_1.
Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R.O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., Agarwal, A., Pietras, E.M., Zhao, J.J., Roberts, T.M., and Gritsman, K., PI3 kinase alpha and delta promote hematopoietic stem cell activation, JCI Insight 2019 doi.org/10.1172/jci.insight.125832
Mitchell, K., Barreyro, L., Todorova, T., Taylor, S., Antony-Debre, I., Narayanagari, S., Carvajal, L., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A., Gritsman, K.,and Steidl, U. IL1RAP potentiates multiple oncogenic signaling pathways in AML, Journal of Experimental Medicine. 2018 May 17. doi: 10.1084/jem.20180147, PMID: 29773641
Hemmati, S., Haque, T., and Gritsman, K, Inflammatory Signaling Pathways in Pre-leukemic and Leukemic Stem Cells, Frontiers in Oncology 2017 Nov 13;7:265. doi: 10.3389/fonc.2017.00265
Bhagat, T.D., Chen, S., Bartenstein, M., Barlowe, A.T., Von Ahrens, D., Choudhary, G.S., Tivnan, P., Amin, E., Marcondes, M., Sanders, M.A., Hoogenboezem, R.M., Kambhampati, S., Ramanchandra, N., Mantzaris, I., Sukrithan, V., Laurence, R., Lopez, R. Bhagat, P., Giricz, O., Sohal, D., Wickrema, A., Yeung, C., Gritsman, K., Aplan, P., Hochedlinger, K., Yu, Y., Pradhan, K., Zhang, J., Greally, J.M., Mukherjee, S., Pellagatti, A., Boultwood, J., Will, B., Steidl, U., Raaijmakers, M.H.G.P., Deeg, H.J., Kharas, M.G. and Verma, A. Epigenetically Aberrant Stroma in MDS Propagates Disease Via Wnt/b-Catenin Activation, 2017 Cancer Research 2017 Jul 6. pii: canres.0282.2017. doi: 10.1158/0008-5472
Stanley, R., Piszczatowski, R., Bartholdy, B., Mitchell, K., McKimpson, W., Narayanagari, S-R., Walter, D., Todorova, T., Hirsch, C., Makishima, H., Will, B., McMahon, C., Gritsman, K., Maciejewski, J., Kitsis, R., and Steidl, U. A myeloid tumor suppressor role for NOL3. 2017 Journal of Experimental Medicine 214 (3):753-771, doi: 10.1084/jem.20162089
Yuzugullu, H., Baitsch, L., Von, T., Steiner, A., Tong, H., Ni, J., Clayton, L., Bronson, R., Roberts, T., Gritsman, K., and Zhao, J.J. A p110b-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis. Nature Communications October 7,2015, doi:10.1038/NCOMMS9501
Cheng, H., Zou, Y., Ross, J.S., Wang, K., Liu, X., Halmos, B., Ali, S.M., Liu, H., Verma, A., Montagna, C., Chachoua, A., Goel, S., Schwartz, E.L., Zhu, C., Shan, J., Yu, Y., Gritsman, K., Yelensky, R., Lipson, D, Otto, G., Hawryluk, M., Stephens, P.J., Miller, V.A., Piperdi, B., Perez-Soler, R., RICTOR amplification defines a novel subset of lung cancer patients who may benefit from treatment with mTOR1/2 inhibitors. Cancer Discovery Published OnlineFirst September 14, 2015; doi:10.1158/2159-8290.CD-14-0971
Pandolfi A, Stanley RF, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U. PAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome. Blood. 2015 Jul 13. pii: blood-2014-12-618801.
Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., Weigert, O., Kopp, N., Wu, S-C., Kim, S., Liu, H., Tivey, T., Christie, A.L., Gritsman, K., Gotlib, J., Deininger, M., Turley, S., Tyner, J., Marto, J., Weinstock, D.M., and Lane, A.A. Mutations in G-protein beta subunits promote transformation and kinase inhibitor resistance Nature Medicine 2015 (1):71-5.
Gritsman, K., Yuzugullu, H., Von, T., Yan, H., Clayton, L., Fritsch, C., Maira, S.-M., Hollingworth, G., Choi, C., Khandan, T., Paktinat, M., Okabe, R.O., Roberts, T.M., and Zhao, J.J. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110alpha. Journal of Clinical Investigation 2014;124(4):1794–1809. http://www.jci.org/articles/view/69927
Kharas, M.G. and Gritsman, K. Akt: A Double-Edged Sword for Hematopoietic Stem Cells. Cell Cycle 2010; Vol 9; Issue 7
Kharas, M.G., Okabe, R., Ganis, J.J., Gozo,M., Khandan,T., Paktinat, M., Gilliland, D.G., and Gritsman, K. Constitutively Active AKT Depletes Hematopoietic Stem Cells and Induces Leukemia in Mice. Blood 2010; 115(7): 1406-15 http://www.bloodjournal.org/content/115/7/1406