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Department of Orthopaedic Surgery

Highlights from 2nd Annual Musculoskeletal Symposium

October 10, 2013 

Symposium brochure - Symposium Mission, Learning Objectives, Agenda, List of Faculty Members, etc. 

Click here for Photo gallery  

 

Young Investigator Award Winners 

Kirsty L. Culley, PhD, Hospital for Special Surgery 

“Defining Common Molecular Parameters for Osteoarthritis Onset and Progression” 

Neha S. Dole, BS, University of Connecticut 

“Osteonectin Single Nucleotide Polymorphism (SNP) Alters Bone Mass: Regulation by miRNA-433” 

Devina Purmessur, PhD, Icahn School of Medicine at Mount Sinai 

“Chondroitin sulfate secreted from intervertebral disc derived notochordal cells inhibits neurite outgrowth from human SH-SY5Y neuroblastoma cells and rat Dorsal Root Ganglion Cells”  

 

Poster Abstracts 

  1. Alternative Splicing, Polyadenlyation, and microRNAs Targeting Insulin-like Growth Factor-1 in Osteoblasts. Spenser S. Smith1, Cathy B. Kessler1, Clifford Rosen2, Anne M. Delany1. 1Center for Molecular Medicine, University of Connecticut Health Center; 2Center for Translational Research, Maine Medical Center Research Institute. 
  2. miRNA-29 Promotes Osteoclastogenesis Through Regulation of Osteoclast Commitment and Migration Tiziana Franceschetti1, Catherine B. Kessler1, Sun-Kyeong Lee2, & Anne M. Delany1. 1Center for Molecular Medicine, 2Center on Aging, University of Connecticut Health Center. 
  3. Osteonectin Single Nucleotide Polymorphism (SNP) Alters Bone Mass: Regulation by miRNA-433. Neha Dole1, Kristina Kapinas1,2, Catherine B. Kessler1, Anne M. Delany1. 1Center for Molecular Medicine, University of Connecticut Health Center; 2Molecular Medicine, University of Massachusetts Medical School. 
  4. The SWI/SNF chromatin remodeling complex and control of osteoblast/adipocyte lineage determination. Kevin Hong Nguyen, Fuhua Xu, Stephen Flowers, Shruti Goel, and Elizabeth Moran. Department of Orthopaedics, New Jersey Medical School Rutgers, The State University of New Jersey, Newark, NJ. 
  5. The effects of weight-bearing exercise on skeletal structure and strength differ between outbred populations of mice. Ian J. Wallace1, Stefan Judex2, Brigitte Demes1. 1Department of Anatomical Sciences, 2Department of Biomedical Engineering, Stony Brook University, NY. 
  6. Age-Related Carbonylation of Fibrocartilage Structural Proteins Drives Tissue Degenerative Modification. Brian Scharf1, Cristina C. Clement1, Sylvia O. Suadicani4, Mia M. Thi2, Giorgio Perino5,  Neil Cobelli2, and Laura Santambrogio1,2,3. Departments of 1Pathology, 2Orthopedic Surgery, 3Microbiology and Immunology, 4Urology. Albert Einstein College of Medicine, Bronx, NY; 5Hospital for Special Surgery, New York, NY. 
  7. A novel mechanotransduction pathway in CITED2 transactivation: Evidence from chondrocytes in response to stretch loading. Zhiyong He1,2,3, Daniel J Leong1,2,3, Marwa Choudhury1,2,3, Lin Xu1,2,3, Hui B Sun1,2,3. 1Department of Orthopaedic Surgery and 2Radiation Oncology, 3Musculoskeletal and Orthopaedic Research Laboratories, Albert Einstein College of Medicine, Bronx, NY. 
  8. Epigallocatechin Gallate (EGCG) Selectively Sensitizes Chondrosarcoma to Ionizing Radiation. Justin Tang1, Zhiyong He1,2,3, Daniel Leong1,2,3, Lin Xu1,2,3, Marwa Choudhury1,2,3, Robert J. Majeska4, David S. Geller2,3, Chandan Guha1, Hui B. Sun1,2,3. 1Departments of Radiation Oncology and 2Orthopaedic Surgery and 3Musculoskeletal and Orthopaedic Research at Einstein-Montefiore, Albert Einstein College of Medicine and Montefiore Medical Center; 4Department of Biomedical Engineering, The City College of New York. 
  9. Pain and behavior assessment of post-trauma Osteoarthritis: basic characters and efficacy of an experimental nutraceuticals drug DX. Marwa Choudhury1,2,4,  Lin Xu1,2,4, Daniel J. Leong1,2,4, Fawzy A. Saad1,4, Regina Hanstein3, David C. Spray3,4 and Hui B. Sun1,2,4. 1Department of Orthopaedic Surgery, 2Department of Radiation Oncology, 3Department of Neuroscience, and 4Musculoskeletal and Orthopaedic Research at Einstein-Montefiore Laboratories.  Albert Einstein College of Medicine, Bronx, NY. 
  10. Role of Sirtuin 1 in the Function of PTH in Osteoblasts. Yurong Fei, Emi Shimizu, Teruyo Nakatani, Nicola C Partridge. New York University College of Dentistry. 
  11. CITED2 is Required for Cartilage Homeostasis: Evidence From CITED2 Deletion in Skeletally Mature Mice. Daniel J. Leong1,2,3,4, Zhiyong He1,2,3, Lin Xu1,2,3, Sally Dunwoodie4, Robert J Majeska4, Mitchell B. Schaffler4, Luis Cardoso4, John A Hardin1,3, Neil J Cobelli1,3, Yu-Chung Yang6, Hui B Sun1,2,3. 1Department of Orthopaedic Surgery and 2Radiation Oncology, 3Musculoskeletal and Orthopaedic Research at Einstein-Montefiore Laboratories, Albert Einstein College of Medicine; 4Department of Biomedical Engineering, The City College of New York; 5Department of Developmental Biology, The University of Adelaide; 6Department of Biochemistry, Case Western Reserve University. 
  12. EGCG Slows Post-traumatic OA Progression in Mice Through a Novel Mechanism Targeting ADAMTS5.Daniel J Leong1,2,3,4, Zhiyong He1,2,3, David Hirsh1,3, Sun Jin Kim1,3, Robert J Majeska4, Mitchell B Schaffler4, John A Hardin1,3, Neil J Cobelli1,3, Hui B Sun1,2,3. 1Department of Orthopaedic Surgery, 2Radiation Oncology, and 3Musculoskeletal Orthopedic Research at Einstein-Montefiore Laboratories, Albert Einstein College of Medicine; 4Department of Biomedical Engineering, The City College of New York. 
  13. Effect of Loading Rates on the Mechanical Behavior of Human Ribs. Gavriel Feuer and Subrata Saha. Department of Orthopaedic Surgery & Rehabilitation Medicine. SUNY Downstate Medical Center, Brooklyn, New York. 
  14. Temporal and spatial regulation of bone acquisition by serum IGF-1 and ovarian hormones. Oran Kenedy1, Garry A. Williams2, Hui Sun2, Louis Cardoso3, Karen Saebo2, Jelena Basta-Pljakic3, Mitchell Schaffler3, and Shoshana Yakar2. 1Department of Orthopaedic Surgery, New York University, Hospital for Joint Diseases, NY; 2David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, Skeletal Phenotyping Core, New York University College of Dentistry, New York, NY; 3Department of Biomedical Engineering, The City College of New York, New York, NY. 
  15. The interactions between the growth hormone/insulin-like growth factor-1 axis and leptin and their effects on peak bone mass. Garry A. Williams1, Hui Sun1, Oran Kenedy2, Louis Cardoso3, Karen Saebo1, Jelena Basta-Pljakic3, Mitchell Schaffler3, and Shoshana Yakar1. 1David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, Skeletal Phenotyping Core, New York University College of Dentistry, New York, NY; 2Department of Orthopaedic Surgery, New York University, Hospital for Joint Diseases, NY; 3Department of Biomedical Engineering, The City College of New York, New York, NY. 
  16. MicroCT of human PC3/M prostate cancer cell metastases in murine tibia. Karen Saebo1, Alice Levine2, Shen Yao2, and Shoshana Yakar1. 1David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, Skeletal Phenotyping Core, New York University College of Dentistry, New York, NY; 2Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY. 
  17. Assessment of Muscle Elasticity Using Ultrasound Elastography. Netanel S Berko1, Erin F FitzGerald1, Terry D Amaral2, Monica Payares2, Terry L Levin1. Departments of Radiology (1) and Orthopaedic Surgery (2), Montefiore Medical Center. 
  18. CITED2 plays a critical role in rejuvenating aged-TSPCs and healing of aged tendon injury. Fawzy A. Saad1; Haixiang Liang1,2, Takuya Ruike1, Daniel J. Leong1,2, Zhiyong He1,2, Marwa Choudhury1,2, Lin Xu1,2, Justin Tang1,2, Robert J. Majeska3, Mia M. Thi1,4, David C. Spray4, Tony S. Wanich1, Konrad I. Gruson1, Evan L. Flatow5, Hui B. Sun1,2. 1Department of Orthopaedic Surgery, 2Department of Radiation Oncology, 4Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY; 3Department of Biomedical Engineering, The City College of New York; 5Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY.  
  19. Loss of Material Properties Due to Diffuse Microdamage in Rat Living Bone Recovers without Osteoclastic Bone Remodeling. Zeynep Seref-Ferlenge, Claudy Philemon, Oran Kennedy, Mitch B. Schaffler. Department of Biomedical Engineering, City College of New York, NY. 
  20. Hematopoietic Stem/Progenitor Cells of Appendicular and Craniofacial Bones. Nan Jiang, Mo Chen, Kimi Kong, Li Hu, Yanheng Zhou, Jeremy J. Mao. Center for Craniofacial Regeneration, Columbia University Medical Center, NY. 
  21. Shear Properties of Cancellous Bone from osteoporotic Sheep Treated with Synthetic Bone Mineral. Gavriel Feuer1, James Bennett1, Subrata Saha1, Dindo Mijares2. 1SUNY Downstate Medical Center, Brooklyn, NY; 2NYU College of Dentistry, New York, NY. 
  22. Osteocytes reveal NADH fluorescence heterogeneity in situ in response to ischemia. Dorra Frikha-Benayed, Jelena Basta-Plajkic, Robert J. Majeska and Mitchell B. Schaffler. Department of Biomedical Engineering, City College of New York, New York, NY. 
  23. Optimal Irrigation And Debridement Of Infected Total Joint Implants With Chlorhexidine Gluconate. Daniel Smith, Richard Maiman, Evan Schwechter, Sun Jin Kim, David Hirsh. Department of Orthopedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York. 
  24. The role of Heat Shock Protein 70 in Heat Enhanced hMSC Osteogenesis. Chenghai Li and Sihong Wang. Department of Biomedical Engineering, City College of CUNY, New York, NY. 
  25. Chondroitin sulfate secreted from intervertebral disc derived notochordal cells inhibits neurite outgrowth from human SH-SY5Y neuroblastoma cells and rat Dorsal Root Ganglion Cells. Devina Purmessur, Marisa C Cornejo, Samuel K Cho, Peter J Roughley, Nicole Goodsell, James C Iatridis. Department of Orthopedics, Mount Sinai School of Medicine, New York, NY. 
  26. Failure Strength Characterization of Composite Repair for Annulus Fibrosus Injury. Rose G. Long1,2, Keegan P. Cole1, Morakot Likhitpanitchkul1,2, Andrew C. Hecht1, James C. Iatridis1,2. 1 Leni and Peter W May Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY; 2Collaborative Research Partner Annulus Fibrosus Rupture Program, AO Foundation, Davos, Switzerland. 
  27. Thermally induced osteocyte apoptosis initiates octeoclastic and osteoblastic responses in vitro. E.B. Dolan1,2, M.G. Haugh1,2, O.D. Kennedy3, L.M. McNamara1,2. 1Centre for Biomechanics Research (BMEC), Mechanical and Biomedical Engineering, NUI Galway, Ireland; 2National Centre for Biomedical Engineering Sciences, NUI Galway, Ireland; 3New York University, Hospital for Joint Diseases, New York. 
  28. Activation of intracortical resorption in mouse long bone by acute placement of focal microdamage by in vivo microindentation is controlled by osteocyte apoptosis. Oran D Kennedy1, Anaya Philip1, J Basta-Pljakic1, Mitchell B Schaffler1. 1Department of Biomedical Engineering, The City College of New York, New York, NY. 
  29. Differential Chondrogenesis of Stem Cells with a Run-X1 Inducing Molecule. 2,3 TA Goldstein, 2J Schwartz, & 1A Gitlin. 1Department of Orthopaedic Surgery, 2Orthopaedic Research Lab at Feinstein Institute for Medical Research, North Shore Long Island, Jewish Health System, Manhasset, NY; 3Hofstra North Shore-LIJ School of Medicine, Hempstead, NY. 
  30. PTH-CBD increases bone mineral density by causing greater increases in bone formation than bone removal in OVX Rats. Robert Gensure*, Ranjitha Katikaneni*, Joshua Sakon**, Uchida  Kentaro*** and Tulasi Ponnapakkam*. *Childrens Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY, USA; ** University of Arkansas, USA; *** Department of Orthopedic Surgery, Kitasato University School of Medicine, Kanagwa, Japan. 
  31. Subcutaneous and Intravenous Single Dose Pharmacokinetics of PTH(1-34) and PTH-CBD, a Long-Acting Parathyroid Hormone Analog, in Sprague Dawley Rats. Tulasi Ponnapakkam*, Ranjitha Katikaneni*, Robert Stratford**, Joshua Sakon***, and Robert Gensure*. *Childrens Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY; **Xavier University of Louisiana, New Orleans, LA; *** University of Arkansas, USA. 
  32. Relationships between Cortical Bone Mechanical Quality and Serum FGF23 in Mice Challenged by Low Calcium and High Fructose Diet. 1,2Edek Williams, 2Veronique Douard, 2Devendra Bajaj, 3Yves Sabbagh, 2Ronaldo P. Ferraris, 1,2J. Christopher Fritton. 1Rutgers University, Department of Biomedical Engineering, 2Rutgers University, New Jersey Medical School, Departments of Orthopaedics & Physiology 3Tissue Protection and Repair, Sanofi-Genzyme R&D Center. 
  33. Pulsed Electromagnetic Field Stimulates Human Osteoblastic Cells and Inhibits Human Osteoclastic Cells. Zhiming He, Nicola C. Partridge. Dept of Basic Science and Craniofacial Biology, New York University College of Dentistry, NY. 
  34. Chronic Ingestion of Advanced Glycation End Products Induces Early Degenerative Spinal Structural Changes. Svenja Illien-Junger, Young Lu, Sheeraz A. Qureshi, Andrew C. Hecht, Weijing Cai, Helen Vlassara, Gary E. Striker, James C. Iatridis. Leni and Peter W May Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY. 
  35. Defining Common Molecular Parameters for Osteoarthritis Onset and Progression. 1Kirsty L. Culley, 1Jun Chang, 1Miguel Otero, 1Cecilia L. Dragomir, 1Jonathan M. Coico, 2Yefu Li, 3Kenneth B. Marcu and 1Mary B. Goldring. 1Hospital for Special Surgery, Weill Cornell Medical College, New York, NY; 2Department of Developmental Biology, Harvard School of Dental Medicine, CT; 3Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY. 
  36. Novel Strategy to Enhance Microfracture Surgery: Use of SDF and Sphingosine In Isolated Cartilaginous Defects. 2John A. Schwartz and 1Noah Chinitz. 1Department of Orthopaedic Surgery, 2Orthopaedic Research Lab at Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY. 
  37. Transient TNFa Exposure Induces Altered Biomechanics and a Sustained Inflammatory Environment in a Dynamic Compression Bioreactor System. Benjamin A Walter, Morakot Likhitpanichkul, Philip Nasser, Andrew C Hecht, James C Iatridis. Leni and Peter W May Dept. of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Biomedical Engineering, The City College of New York, New York, NY 
  38. Regulation of Human Tendon Fibroblast Response by Fiber Diameter of Electrospun Polymer Scaffolds. N.M. Lee, C.E. Erisken, W.N. Levine, H.H. Lu. Biomaterials and Interface Tissue Engineering Laboratory, Columbia University, New York, NY. 
  39. Effect of Ceramic Proximity on Deep Zone Chondrocyte Response. Margaret K. Boushell1, Mary M. Quien1, Helen H. Lu1. 1Biomaterials and Interface Tissue Engineering Laboratory, Columbia University, New York, NY. 
  40. Alendronate Treatment Elicits a Reduction in Mechanical Properties and the Density of Osteocyte Lacuna in Cortical Tissue. 1,2Joseph Geissler, 1Devendra Bajaj, 3Matthew Allen, 3David Burr and 1,2J. Christopher Fritton. 1Rutgers University, New Jersey Medical School, Department of Orthopaedics, Newark, NJ; 2New Jersey Institute of Technology, Department of Biomedical Engineering, Newark, NJ; 3Indiana University of Medicine, Department of Anatomy and Cell Biology, Indianapolis, IN. 
  41. High Glucose Levels Associated with Type I Diabetes alter Bone Cell Mechanosignaling mediators. Stephanie Maung1; David C Spray3,5; Sylvia O Suadicani3,4,5; Mia M Thi2,3,5. 1Department of Biology, Stony Brook University, NY, United States; Departments of 2Orthopaedic Surgery, 3Neuroscience, 4Urology, and 5Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY. 
  42. Effects of Mild Heating on the Osteogenesis of Mesenchymal Stem Cells During Inflammation. Kristifor Sunderic, Dionne Dawkins, Sihong Wang. Department of Biomedical Engineering, City College of CUNY, New York, NY. 
  43. The Alterations of Gene Expressions of Osteogenic Growth Factors and Transcription Factors in Response to Dynamic Hydraulic Stimulation. Minyi Hu, Yi-Xian Qin. Orthopaedic Bioengineering Research Laboratory, Dept. of Biomedical Engineering, Stony Brook University, Stony Brook, NY. 
  44. Influences of Vertebral Endplate Microvessels on the Development of Degenerative Disc Diseases. F. Xavier, S. Hossain, R. Rousseau, D. Chatterjee, and S. Saha. Department of Orthopaedic Surgery & Rehabilitation Medicine, SUNY Downstate Medical Center, NY. 
  45. Generation of muscle using synthetic biology. Vladimir Grubišić1, Manoj K Gottipati, Randy F. Stout Jr.1,3 J. Robert Grammer1, Vladimir Parpura1,2. 1Department of Neurobiology and 2Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham AL; 3Current Address: Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY. 
  46. The Use of BMP-2 and Novel Polymers for Guided Bone Regeneration. 1,2S Subramanian, 3AM Mitchell, 1,4SS Snyder, 4KE Uhrich, 3 JP O’Connor. 1Rutgers, The State University of New Jersey, Graduate School of Biomedical Sciences, Newark, NJ; 2New Jersey Institute of Technology, Department of Biomedical Engineering, Newark, NJ; 3Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ; 4Rutgers, The State University of New Jersey, Department of Chemistry and Chemical Biology, Piscataway, NJ. 

 

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