The Dominick P. Purpura Department of Neuroscience is proud to welcome three new faculty members to our community:
Dr. Radulovic will join the Einstein faculty as Professor in the Department of Neuroscience and Department of Psychiatry and Behavioral Sciences, and Director of PRIME in November. The main goal of her research is to discover the neurobiological mechanisms by which memories of stressful events alter affective states to cause fear, anxiety, and depression. Dr. Radulovic completed her MD and PhD degrees at University of Belgrade, Serbia, working on the effects of stress on immunological functions under the supervision of Dr. Branislav D. Jankovic. She continued her work on stress as a postdoctoral fellow at the Max Planck Institute for Experimental Medicine in the group of Dr. Joachim Spiess, focusing on the neuroendocrine and behavioral aspects of stress. As an independent group leader, she subsequently developed a program centered on the role of memory systems in emotional behavior. She continued this line of research at Northwestern University, Department of Psychiatry and Behavioral Sciences, where she was appointed as the Dubar Professor of Bipolar Disease. Dr. Radulovic's research at Einstein will be centered on both fundamental questions related to the neurobiology of stress and memory, as well as models of translational relevance for human mental health. Through the fundamental understanding of the neurobiology of stress-related memory at the molecular/cellular, circuit, and system levels, the Radulovic lab aims to identify new treatment approaches of affective disorders.
Our translational laboratory uses systems neuroscience tools to better understand the pathophysiology and biology that underlies the full spectrum of eating disorders from anorexia to obesity in hopes of improving treatment and reducing stigma. We are focused on how neuropeptides regulate specific circuits at the interface of stress and metabolism, with an interest in sex differences and behavior differences that result in outcomes across the weight spectrum related to psychiatric and medical illness. In rodent models we use a combination of behavior studies, electrophysiology, in vivo calcium imaging, pharmacologic, optogenetic, and chemogenetic manipulations to interrogate how these neuropeptides regulate neural circuits at the interface of stress and metabolism. In collaboration with clinical researchers, we work to apply our findings to inform investigations into human behavior using molecular, genetic, and qualitative approaches.
Stephanie joined the Department of Neuroscience and the Department of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine as Assistant Professor in July 2020. Stephanie completed her doctoral training with Jacques Wadiche at the University of Alabama at Birmingham and Peter Jonas at the University of Freiburg, Germany. She used electrophysiology to investigate the impact of neuronal activity patterns on the kinetics of neurotransmitter release. Towards the end of her Ph.D., Stephanie shifted her focus on the inhibitory circuits that shape cerebellar output. In Wade Regehr’s laboratory at Harvard Medical School, Stephanie began using a combination of 2-photon imaging and electrophysiology to study the intrinsic and synaptic properties of interneurons that control the integration of multisensory input in local circuits. Her recent work has focused on how a slow and persistent form of GABAergic inhibition that is disrupted in many neurodevelopmental and psychiatric disorders shapes anxiety-like, social and parental behaviors. In her new lab, Stephanie will investigate how context-specific neuromodulators shape cerebellar function to regulate social and aggressive behaviors, and examine the long-range circuits that allow the cerebellum to control these behaviors.