HIV-Associated Comorbidities, Coinfections and Complications A complex array of coinfections and comorbid conditions, including end-organ dysfunction, adversely affect the clinical course of HIV. ART significantly improves but does not eliminate the development of HIV-associated comorbidities, coinfections, and complications (CCCs) which entails clinical management of concurrent HIV-associated CCCs across the lifespan. Several ERC-CFAR investigators are focused on determining the mechanistic basis and ameliorating the impact of infections such as tuberculosis (TB), hepatitis B and C, human papillomavirus (HPV), and sexually transmitted infections (STIs) on HIV disease course. Increasing our understanding of the underlying mechanisms responsible for how coinfections and comorbid conditions impact on clinical course should lead to improved treatment and prevention of HIV infection and these related disorders. In addition, ERC-CFAR Investigators are engaged in research relevant to other coinfections and opportunistic infections and HIV-related cancers, neurologic and cognitive disorders, cardiovascular disease, mental illness and substance use, metabolic and bone abnormalities, and liver and renal dysfunction. Listed below are NIH-funded studies by our ERC-CFAR Investigators researching strategies to address HIV-associated Comorbidities, Coinfections, and Complications. Investigator Institution NIH Grant Title Jacqueline Achkar Einstein R01AI117927 Host biomarkers for M. Tuberculosis infection activity in HIV-infected persons Kathryn Anastos Einstein U01HL146204 Clinical research sites for the MACS/WIHS combined cohort study (MACS/WIHS-CCS) Kathryn Anastos Einstein U54CA254568 Einstein/Rwanda DRC consortium for research in HIV/HPV malignancies - project 2 Kathryn Anastos Einstein U01AI096299 Central AFRICA international epidemiologic database to evaluate AIDS Joan Berman Einstein R01DA041931 Effect of buprenorphine on monocytes in the context of neuroAIDS and opioid abuse Joan Berman Einstein R01DA044584 Impact of illicit drugs, HIV, and ART on neuroinflammation and BBB disruption Joan Berman Einstein R01DA048609 Mechanisms of opioid- mediated HIV neuropathogenesis Joan Berman Einstein R01MH112391 Monocyte CNS HIV entry & neurodegeneration: translational studies in the cART era James Brust Einstein K24AI155045 Mentoring of multidisciplinary global health research in tuberculosis and HIV James Brust Einstein R01AI145679 Emergence of bedaquiline and clofazimine resistance after interruption of drug-resistant tb therapy in a high HIV prevalence setting Vilma Gabbay Einstein R01DA054885 The neural underpinnings of depression and cannabis use in young PLWH Vilma Gabbay Einstein R01MH128878 The neuroimmunology of depression in women living with HIV David Hanna Einstein K01HL137557 Prediction of heart failure in HIV-infected individuals Betsy Herold Einstein R01AI134367 Mechanisms underlying the HIV-HSV-2 syndemic Robert Kaplan Einstein R01HL148094 Immunophenotyping for precision medicine for cardiovascular disease in people living with HIV Pedro Mateu-Gelabert CUNY SPH R01DA041501 The staying safe intervention: preventing HCV among young opioid injectors Kerry Murphy Einstein K23AG062400 The impact of HIV on accelerated aging in the female genital tract: a pilot trial of topical estradiol to improve the vaginal microbiome and symptoms of vaginal atrophy in menopausal women with HIV Liise-Anne Pirofski Einstein R01AI143453 Antibodies, B cells and resistance to human cryptococcosis Qibin Qi Einstein R01HL140976 Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites Joanna Starrels Einstein K24DA046309 Mentoring junior investigators to tackle the opioid epidemic Howard Strickler Einstein R01CA230331 Next generation of HPV and cervical cancer research in HIV+ women Marcel Yotebieng Einstein R01HD087993 Long term outcomes of therapy in women initiated on lifelong ART because of pregnancy in DR Congo Marcel Yotebieng Einstein R01HD105526 HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic study