Clinical and Translational Science Core

To help meet the United States government’s goal of Ending the HIV Epidemic (EHE), the Einstein-Rockefeller-CUNY Center for AIDS Research (ERC-CFAR) has formed strong collaborations both within and beyond our partner institutions, including with the New York City Department of Health and Mental Hygiene and the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University, to catalyze and support research that best serves the public’s health: to eradicate HIV infection, prevent new HIV infections, and improve the health of people living with HIV (PWH).

The overarching goal of the ERC-CFAR and the Clinical and Translational Science Core (CTSC) is to support the EHE mission by creating a broad and robust HIV clinical research resource available to researchers locally, nationally and globally. Our synergistic partnership provides a broad range of support for clinical, translational, health services, and implementation science investigations. By leveraging the resources of the Einstein CTSA-funded Harold and Muriel Block Institute for Clinical and Translational Research, the CTSC provides access to a robust study design consultative service, clinical database and multiple biorepositories.

For further information, please contact our study coordinator, Ms. Yocheved Halberstam, at cfar-clinical-core@einsteinmed.org.

Through CTSC resources, the clinical population at Montefiore/Einstein is linked to the cutting-edge research in HIV eradication HIV clinical trials being conducted at Rockefeller University, which lacks access to defined cohorts of PWH. The CTSC also links this population to research studies being performed by investigators at City University of New York (CUNY), leaders in implementation science who are assessing the factors that influence our ability to impact favorably on the public’s health with interventions of proven efficacy. The CTSC is integrated into the HIV and Mental Health Scientific Working Group, a driver of the ERC-CFAR’s scientific direction, to provide optimal support to foster the emerging research activities of SWG members, and foster scientific cross-fertilization among cores and the SWG. We leverage Einstein’s Center for Health Data Innovations and use of state-of-the-art informatics methods, including natural language processing and machine learning, to catalyze and facilitate new research in primary prevention of HIV infection, while maintaining our extensive support of well-established research areas.

HIV Clinical Cohort Database

The Clinical Cohort Database (CCDB), derived from the Montefiore/Einstein clinical services, contains >20,000 PWH and 484,000 HIV-negative patients; >6,300 PWH are in active care; 43% are women, 48% Hispanic/Latinx and 41% African American. This comprehensive, longitudinal database provides ERC-CFAR investigators with access to Montefiore’s extensive clinical infrastructure and has catalyzed an explosion of clinical, epidemiologic, translational, health services, and implementation science research on HIV treatment, epidemiology and prevention. In addition, we facilitate enrollment of well-characterized patients (including HIV-negative controls) into new research protocols, particularly treatment and PrEP studies.

Our summary slides contain a detailed overview of the database and summary statistics for our populations.

To propose a project utilizing the HIV Clinical Cohort Database, please complete the Collaboration Concept Sheet Submission Form. Please direct all inquiries to the study coordinator at cfar-clinical-core@einsteinmed.org.

Recent publications supported by the Clinical and Translational Science Core

  • *Bortnick AE, Shahid M, Shitole SG, Park M, Broder A, Rodriguez CJ, Scheuer J, Faillace R, Kizer JR (2020). Outcomes of ST‐elevation myocardial infarction by age and sex in a low‐income urban community: The Montefiore STEMI Registry. Clin Cardiol 43: 1100-1109. Pubmed
  • *Chyten-Brennan J, Patel VV, Ginsberg MS, Hanna DB (2021). Algorithm to identify transgender and gender nonbinary individuals among people living with HIV performs differently by age and ethnicity. Ann Epidemiol 54: 73- 78. Pubmed
  • *Fisher MC, Fazzari MJ, Hanna DB, Patel VV, Felsen UR, Alahiri E, Byju A, Akiyama MJ, Ginsberg MS, Anastos K, Ross MJ (2021). Acute kidney injury in people living with HIV hospitalized with coronavirus disease 2019: Clinical characteristics and outcomes. JAIDS 87: 1167-1172. Pubmed
  • *Furukawa NW, Smith DK, Gonzalez CJ, Huang YA, Hanna DB, Felsen UR, Zhu W, Arnsten JH, Patel VV (2020). Evaluation of algorithms used for PrEP surveillance using a reference population from New York City — July 2016–June 2018. Pub Health Rep 135: 202-210. Pubmed
  • Hanna DB, Ramaswamy C, Kaplan RC, Kizer JR, Daskalakis DC, Anastos K, Braunstein SL (2020). Sex- and poverty-specific patterns in HIV-associated cardiovascular mortality in New York City, 2007-2017. Clin Infect Dis 27: 491-498. Pubmed
  • *Klugman M, Fazzari M, Xue X, Ginsberg M, Rohan T, Halmos B, Hanna DB, Shuter J, Hosgood HD (2021). The associations of CD4 count, CD4/CD8 ratio, and HIV viral load with survival from non-small cell lung cancer in persons living with HIV. AIDS Care, ePub 1 Jun 2021. Pubmed
  • *Patel VV, Felsen UR, Fisher M, Fazzari MJ, Ginsberg MS, Beil R, Akiyama MJ, Anastos K, Hanna DB (2021). Clinical outcomes and inflammatory markers by HIV serostatus and viral suppression in a large cohort of patients hospitalized with COVID-19. JAIDS 86: 224-230. Pubmed
  • *Shitole SG, Kuniholm MH, Hanna DB, Boucher T, Peng AY, Berardi C, Shah T, Bortnick AE, Panagiota C, Scheuer J, Kizer JR (2020). Association of human immunodeficiency virus and hepatitis C virus infection with long-term outcomes post-ST segment elevation myocardial infarction in a disadvantaged urban community. Atherosclerosis 311: 60-66. Pubmed

*Uses the HIV Clinical Cohort Database.

COMPLETE LIST OF PUBLICATIONS SUPPORTED BY THE CLINICAL AND TRANSLATIONAL SCIENCE CORE