Life Course Methodology Core (LCMC) LEADERSHIP Carmen R. Isasi, MD, PhD Albert Einstein College of MedicineDirector FACULTY Shivani Agarwal, MD Albert Einstein College of MedicineCore Faculty Karen A. Bonuck, PhD Albert Einstein College of MedicineCore Faculty Judith Wylie-Rosett, EdD, RDN Albert Einstein College of MedicineCore Faculty Yasmin Mossavar-Rahmani, PhD Albert Einstein College of MedicineCore Faculty Leonard Epstein, PhD University of Buffalo Core faculty AIMS The overall goal of the LCMC is to support high quality type 2 translational research in diabetes across the lifespan. The life course perspective focuses on biopsychosocial and behavioral processes that individuals experience during particular periods in their life. It examines the intersection between social determinants of health and the biological processes that shape disease risk, which are fundamental to understand health disparities. Not only does the relative importance of specific factors vary across the lifespan, but exposures and behaviors in later life may mediate or moderate the effects of exposures and behaviors that occurred at younger ages. Thus, to optimally prevent the development of diabetes (primary prevention) and its sequelae (secondary and tertiary prevention), interventions must be appropriately targeted to the specific life course stage and must consider the downstream effects of exposures acting earlier in life. By identifying targets for intervention relevant to specific life span periods, the life course approach facilitates interventions for diabetes prevention or control within vulnerable age groups. This approach can also enhance the translation of efficacious interventions by ensuring that intervention strategies are developmentally tailored and that they address associated individual or environmental barriers. SERVICES PROVIDED We provide consultations to facilitate identification of key elements for translating interventions across the life course: Adapting study designs to life course Facilitating the implementation of life course methodology Providing consultation on the use of biomarkers Resources The LCMC collaborates with the Einstein Institute for Clinical and Translational Research (ICTR) and other centers at Einstein to provide specific support for investigators. Grant Acknowledgement Users of Core Services are asked to acknowledge the support of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant that supports our Center in their publications and presentations: P30 DK111022. Contact Us For any questions, feel free to call or e-mail us at: cellbio@einsteinmed.org 718.430.2815 718.430.8574 (Fax) Division Administration Our Address Department of Cell Biology Albert Einstein College of Medicine 1300 Morris Park Avenue Chanin Building, Room 405 New York, NY 10461